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. 2019 Mar;13(2):133-137.
doi: 10.1111/irv.12616. Epub 2018 Dec 19.

Hospitalization following outpatient medical care for influenza: US influenza vaccine effectiveness network, 2011-12-2015-16

Grace D Appiah  1   2 , Jessie R Chung  2 , Brendan Flannery  2 , Fiona P Havers  2 , Richard K Zimmerman  3 , Mary Patricia Nowalk  3 , Arnold S Monto  4 , Emily T Martin  4 , Manjusha Gaglani  5 , Kempapura Murthy  5 , Lisa A Jackson  6 , Michael L Jackson  6 , Huong Q McLean  7 , Edward A Belongia  7 , Alicia M Fry  2
Affiliations

Hospitalization following outpatient medical care for influenza: US influenza vaccine effectiveness network, 2011-12-2015-16

Grace D Appiah et al. Influenza Other Respir Viruses. 2019 Mar.

Abstract

Over five seasons, we determined the proportion of outpatients with laboratory-confirmed, influenza-associated illness who were hospitalized within 30 days following the outpatient visit. Overall, 136 (1.7%) of 7813 influenza-positive patients were hospitalized a median of 4 days after an outpatient visit. Patients aged ≥ 65 years and those with high-risk conditions were at increased risk of hospitalization. After controlling for age and high-risk conditions, vaccination status and infecting influenza virus type were not associated with hospitalization risk among adults.

Keywords: hospitalization; influenza; medically attended acute respiratory illness; outpatients.

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Conflict of interest statement

EAB, MG, and HQM have received research funds from MedImmune, LLC. ETM, MPN, and RZ have received research funds from Merck & Co., Inc. LAJ has received research funds from Novavax. ETM has received research funds from Roche Pharmaceuticals. ASM and RZ have received research funds from Sanofi Pasteur, Inc. ASM has received personal fees from Novartis and Protein Sciences Corporation. RZ has received research funds from Pfizer Inc. The remaining authors report no conflict of interests.

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