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. 2018:53:179-181.
doi: 10.1016/j.ijscr.2018.10.033. Epub 2018 Oct 25.

A rare case of primary thyroid amyloidosis

M A Cannizzaro  1 , S Lo Bianco  2 , W Saliba  3 , S D'Errico  2 , F Pennetti Pennella  2 , G Buttafuoco  3 , D Provenzano  2 , G Magro  3
Affiliations

A rare case of primary thyroid amyloidosis

M A Cannizzaro et al. Int J Surg Case Rep. 2018.

Abstract

Introduction: Amyloid goiter is due to the deposition of amyloid in the thyroid, resulting with enlargement of the gland and compressive symptoms.

Case: We herein present a case of a 45-year-old male patient who complained of a big swelling in the neck. Ultrasound showed an enlarged thyroid gland with mediastinal involvement. The multinodular appearance was consistent with the diagnosis of multinodular goiter. He had a history of multiple myeloma but no sign of systemic amyloidosis.

Discussion: Thyroid gland was removed and the histopathological examination revealed a diffuse deposition of amyloid associated with metaplastic lipomatosis of the stroma.

Conclusions: The treatment of choice in patients with amyloid goiter is total thyroidectomy to solve compression symptoms.

Keywords: Amyloidosis; Goiter; Primary amyloidosis; Thyroid; Thyroid disease.

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Figures

Fig. 1
Fig. 1
A. Stroma of the thyroid is largely replaced by amorphous eosinophilic material. Residual follicles, some of which with cystic changes, can be seen.
See this image and copyright information in PMC

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