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Review
. 2018 Nov 8;9(1):302.
doi: 10.1186/s13287-018-1044-5.

A review: therapeutic potential of adipose-derived stem cells in cutaneous wound healing and regeneration

Peng Li  1 , Xiutian Guo  2
Affiliations
Review

A review: therapeutic potential of adipose-derived stem cells in cutaneous wound healing and regeneration

Peng Li et al. Stem Cell Res Ther. .

Abstract

As the most important barrier for the human body, the skin often suffers from acute and chronic injuries, especially refractory wounds, which seriously affect the quality of life of patients. For these refractory wounds that cannot be cured by various surgical methods, stem cell transplantation becomes an effective research direction. As one of the adult stem cells, adipose-derived stem cells play an indispensable role in the repair of skin wounds more than other stem cells because of their advantages such as immune compatibility and freedom from ethical constraints. Here, we actively explore the role of adipose-derived stem cells in the repair of cutaneous wound and conclude that it can significantly promote cutaneous wound healing and regeneration. Based on a large number of animal and clinical trials, we believe that adipose-derived stem cells will have a greater breakthrough in the field of skin wound repair in the future, especially in chronic refractory wounds.

Keywords: Adipose-derived stem cells; Clinical trials; Cutaneous wound healing; Regeneration; Stromal vascular fraction.

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The authors declare that they have no competing interests.

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References

    1. Bourin Philippe, Bunnell Bruce A., Casteilla Louis, Dominici Massimo, Katz Adam J., March Keith L., Redl Heinz, Rubin J. Peter, Yoshimura Kotaro, Gimble Jeffrey M. Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT) Cytotherapy. 2013;15(6):641–648. doi: 10.1016/j.jcyt.2013.02.006. - DOI - PMC - PubMed
    1. Atalay S, Coruh A, Deniz K. Stromal vascular fraction improves deep partial thickness burn wound healing. Burns. 2014;40(7):1375–1383. doi: 10.1016/j.burns.2014.01.023. - DOI - PubMed
    1. Chae DS, Han S, Son M, et al. Stromal vascular fraction shows robust wound healing through high chemotactic and epithelialization property. Cytotherapy. 2017;19(4):543–554. doi: 10.1016/j.jcyt.2017.01.006. - DOI - PubMed
    1. Tan Shaun S., Yeo Xin Yi, Liang Zhen Chang, Sethi Sunil K., Tay Samuel S.W. Stromal vascular fraction promotes fibroblast migration and cellular viability in a hyperglycemic microenvironment through up-regulation of wound healing cytokines. Experimental and Molecular Pathology. 2018;104(3):250–255. doi: 10.1016/j.yexmp.2018.03.007. - DOI - PubMed
    1. Singer AJ, Raf C. Mechanisms of disease: cutaneous wound healing. New Engl J Med. 1999;341(341):738–746. doi: 10.1056/NEJM199909023411006. - DOI - PubMed

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