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. 2019 Feb;42(2):e16-e17.
doi: 10.2337/dc18-0373. Epub 2018 Nov 8.

Zinc Transporter 8 Autoantibodies (ZnT8A) and a Type 1 Diabetes Genetic Risk Score Can Exclude Individuals With Type 1 Diabetes From Inappropriate Genetic Testing for Monogenic Diabetes

Kashyap A Patel  1 , Michael N Weedon  1 , Beverley M Shields  1   2 , Ewan R Pearson  3 , Andrew T Hattersley  1   2 , Timothy J McDonald; UNITED study team
Affiliations

Zinc Transporter 8 Autoantibodies (ZnT8A) and a Type 1 Diabetes Genetic Risk Score Can Exclude Individuals With Type 1 Diabetes From Inappropriate Genetic Testing for Monogenic Diabetes

Kashyap A Patel et al. Diabetes Care. 2019 Feb.
No abstract available

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Conflict of interest statement

Duality of Interest. No potential conflicts of interest relevant to this article were reported.

Figures

Figure 1
Figure 1
Benefit of ZnT8A and T1D-GRS in addition to GADA/IA-2A for excluding individuals with T1D from genetic test for monogenic diabetes who have significant endogenous secretion in the UNITED study.
See this image and copyright information in PMC

References

    1. Shields BM, Shepherd M, Hudson M, McDonald TJ, Colclough K, Peters J, et al. Population-Based Assessment of a Biomarker-Based Screening Pathway to Aid Diagnosis of Monogenic Diabetes in Young-Onset Patients. Diabetes Care. 2017 Aug;40(8):1017–25. American Diabetes Association. - PMC - PubMed
    1. Vermeulen I, Weets I, Asanghanwa M, Ruige J, Van Gaal L, Mathieu C, et al. Contribution of antibodies against IA-2beta and zinc transporter 8 to classification of diabetes diagnosed under 40 years of age. Diabetes Care. 2011 Aug;34(8):1760–5. American Diabetes Association. - PMC - PubMed
    1. Patel KA, Oram RA, Flanagan SE, De Franco E, Colclough K, Shepherd M, et al. Type 1 Diabetes Genetic Risk Score: A Novel Tool to Discriminate Monogenic and Type 1 Diabetes. Diabetes. 2016 Jul;65(7):2094–9. American Diabetes Association. - PMC - PubMed
    1. Oram RA, Patel K, Hill A, Shields B, McDonald TJ, Jones A, et al. A Type 1 Diabetes Genetic Risk Score Can Aid Discrimination Between Type 1 and Type 2 Diabetes in Young Adults. Diabetes Care. 2016 Mar;39(3):337–44. - PMC - PubMed