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Review
. 2018 Oct 10;9(21):3894-3897.
doi: 10.7150/jca.26854. eCollection 2018.

Classification of Solitary Plasmacytoma, Is it more Intricate than Presently Suggested? A Commentary

Nissim Ohana  1 , Ory Rouvio  2 , Karen Nalbandyan  3 , Dimitri Sheinis  1 , Daniel Benharroch  3
Affiliations
Review

Classification of Solitary Plasmacytoma, Is it more Intricate than Presently Suggested? A Commentary

Nissim Ohana et al. J Cancer. .

Abstract

A query regarding the definition and the classification of solitary plasmacytoma is apparently still pending. The clinical course, the response to treatment and the propensity to progress to plasma cell myeloma, are all a function of the classification which must be established on a firm basis. Solitary plasmacytoma should be recognized in the continuum of the plasma cell neoplasms. Moreover, whether the solitary plasmacytoma of bone and the extramedullary type of the tumor represent two distinct disease entities, exhibiting separate biological characteristics, has not been finally established. To appraise the similarities and differences between these two types of lesion, we have scrutinized recent investigations relating their classification. A commentary highlighting our conclusions follows.

Keywords: occult bone marrow disease; solitary plasmacytoma; solitary plasmacytoma of bone.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

References

    1. McKenna RW, Kroft SH, Linden MA. Solitary plasmacytoma. In: Jaffe ES, Arber DA, Campo E, Harris NL, Quintanilla-Martinez L, editors. Hematopathology, 2nd ed. Philadelphia: Elsevier; 2017. pp. 496–498.
    1. McKenna RW, Kyle RA, Kuehl WM, Harris NL, Coupland RW, Fend F. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edit update, Lyon, IARC; 2017. Plasmacytoma; pp. 250–253.
    1. Rajkumar SV, Dimopoulos MA, Palumbo A. et al. International Myeloma Working Group Updated Criteria for the Diagnosis of Multiple Myeloma. Lancet Oncol. 2014;15:e538–548. - PubMed
    1. Pavia B, Chandia M, Vidriales M-B. et al. Multiparameter flow cytometry for staging of solitary bone plasmacytoma: new criteria for risk of progression to myeloma. Blood. 2014;124:1300–1303. - PubMed
    1. Hill QA, Rawstron AC, de Tute RM, Owen RG. Outcome prediction in plasmacytoma of bone: a risk model utilizing bone marrow flow cytometry and light chain analysis. Blood. 2014;124:1296–1299. - PubMed