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. 2018 Oct 5;9(78):34699-34707.
doi: 10.18632/oncotarget.26165.

β-amyloid wall deposit of temporal artery in subjects with spontaneous intracerebral haemorrhage

Antonino Tuttolomondo  1 , Rosario Maugeri  2 , Elisabetta Orlando  3 , Giulio Giannone  3 , Francesco Ciccia  4 , Aroldo Rizzo  5 , Domenico Di Raimondo  1 , Francesca Graziano  2 , Rosaria Pecoraro  1 , Carlo Maida  1 , Irene Simonetta  1 , Anna Cirrincione  1 , Francesca Portelli  3 , Francesca Corpora  1 , Domenico Gerardo Iacopino  2 , Antonio Pinto  1
Affiliations

β-amyloid wall deposit of temporal artery in subjects with spontaneous intracerebral haemorrhage

Antonino Tuttolomondo et al. Oncotarget. .

Abstract

Background: Cerebral Amyloid Angiopathy has been indicated as an important cause of spontaneous non-hypertensive intracerebral haemorrhage (ICH).

Aims: to analyze the presence of β-amyloid deposit in the temporal artery of consecutive patients with ICH in comparison to control subjects and its relation to APO-E haplotype frequency.

Methods: We enrolled consecutive patients admitted to Neurosurgery Ward of University Hospital "P. Giaccone" of Palermo with a diagnosis of spontaneous non hypertensive ICH and as control 12 subjects without brain haemorrhage. Biopsy of superficial temporal artery has been performed and β-amyloid deposit was quantified.

Results: Among 25 subjects with ICH, 10 (40%) had APOE epsilon 2 allele and among these subjects 7 (70%) showed amyloid accumulation on temporal artery specimens, 8 (32%) subjects had APOE epsilon 3 allele and among these subjects only 2 (25%) showed amyloid accumulation on temporal artery specimens, whereas 7 (28%) had APOE epsilon 4 allele and of these, 7 (100%) showed amyloid accumulation on temporal artery specimens. At multivariable logistic regression analysis for the presence of amyloid, predictive factors for the presence of amyloid in temporal artery biopsies were: age, hypertension, intralobar site of haemorrhage, APOE epsilon 2 and APOE epsilon 4 alleles.

Discussion: Our findings of a higher frequency of amyloid deposition in temporal artery specimens in subjects with spontaneous intracerebral haemorrhage indicate a possible role of temporal artery as a possible diagnostic site of biopsy in subjects at high risk to develop intracranial haemorrhage related to Cerebral Amyloid Angiopathy.

Keywords: CAAH; intracerebral haemorrhage; superficial temporal artery; β-amyloid.

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Conflict of interest statement

CONFLICTS OF INTEREST None.

Figures

Figure 1
Figure 1. Superficial temporal artery specimen from a 67 year old male patient with spontaneous intracerebral haemorrhage and apo ε2 genotype
(A) Congophilic amorphous material in the muscular wall of the superficial temporal artery. (B) The polarized light evidences a linear “apple green” birefringence, related to amyloid deposites. (Congo Red, 100x).
Figure 2
Figure 2. Superficial temporal artery specimen from a 68 year old female patient with spontaneous intracerebral haemorrhage and apo ε4 genotype
(A) Congophilic amorphous material in the muscular wall of the superficial temporal artery. (B) The polarized light evidences week granular “apple green” birefringence, related to amyloid deposites. (A, B: Congo Red, stain 200x).
See this image and copyright information in PMC

References

    1. Feigin VL, Lawes CM, Bennett DA, Barker-Collo SL, Parag V. Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review. Lancet Neurol. 2009;8:355–369. - PubMed
    1. Steiner T, Al-Shahi Salman R, Beer R, Christensen H, Cordonnier C, Csiba L, Forsting M, Harnof S, Klijn CJ, Krieger D, Mendelow AD, Molina C, Montaner J, et al. European Stroke Organisation European Stroke Organisation (ESO) guidelines for the management of spontaneous intracerebral haemorrhage. Int J Stroke. 2014;9:840–855. - PubMed
    1. Qureshi AI, Mendelow AD, Hanley DF. Intracerebral haemorrhage. Lancet. 2009;373:1632–1644. - PMC - PubMed
    1. Adeoye O, Broderick JP. Advances in the management of intracerebral haemorrhage. Nat Rev Neurol. 2010;6:593e601. - PubMed
    1. de Oliveira Manoel AL, Goffi A, Zampieri FG, Turkel-Parrella D, Duggal A, Marotta TR, Macdonald RL, Abrahamson S. The critical care management of spontaneous intracranial hemorrhage: a contemporary review. Crit Care. 2016;20:272. - PMC - PubMed