Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jun 25;8(1):1341758.
doi: 10.1080/20022727.2017.1341758. eCollection 2017.

Transgene and islet cell delivery systems using nano-sized carriers for the treatment of diabetes mellitus

Kiyonori Ito  1 , Susumu Ookawara  1 , Kenichi Ishibashi  2 , Yoshiyuki Morishita  1
Affiliations
Review

Transgene and islet cell delivery systems using nano-sized carriers for the treatment of diabetes mellitus

Kiyonori Ito et al. Nano Rev Exp. .

Abstract

Gene therapy that targets the pancreas and intestines with delivery systems using nano-sized carriers such as viral and non-viral vectors could improve the control of blood glucose levels, resulting in an improved prognosis for patients with diabetes mellitus. Allogenic pancreatic islet cell transplantations using such delivery systems have been developed as therapeutic options for diabetes mellitus. This review focuses on transgenes and islet cell delivery systems using nano-sized carriers for the treatment of diabetes mellitus.

Keywords: Diabetes mellitus; allogenic pancreatic islet cell transplantation; delivery system; gene therapy; non-viral vector; viral vector.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Viral and non-viral vectors for the treatment of renal fibrosis in vivo.
See this image and copyright information in PMC

References

    1. Collaboration NCDRF Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants. Lancet. 2016. April 9;387(10027):1–11. PubMed PMID: 27061677. - PMC - PubMed
    1. Group AC, Patel A, MacMahon S, et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008. June 12;358(24):2560–2572. PubMed PMID: 18539916. - PubMed
    1. Ohkubo Y, Kishikawa H, Araki E, et al. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Pract. 1995. May;28(2):103–117. PubMed PMID: 7587918. - PubMed
    1. Wong JK, Mohseni R, Hamidieh AA, et al. Will nanotechnology bring new hope for gene delivery? Trends Biotechnol. 2017. January 17;35:434–451. PubMed PMID: 28108036.; eng. - PubMed
    1. Tang Y, Zeng Z, He X, et al. SiRNA crosslinked nanoparticles for the treatment of inflammation-induced liver injury. Adv Sci (Weinh). 2017. February;4(2):1600228 PubMed PMID: 28251047; PubMed Central PMCID: PMC5323819. eng. - PMC - PubMed

LinkOut - more resources