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. 2018 Oct 15:2018:7302045.
doi: 10.1155/2018/7302045. eCollection 2018.

The Correlations of Plasma and Cerebrospinal Fluid Amyloid-Beta Levels with Platelet Count in Patients with Alzheimer's Disease

Hao-Lun Sun  1 , Wei-Wei Li  1 , Chi Zhu  1 , Wang-Sheng Jin  1 , Yu-Hui Liu  1 , Fan Zeng  1 , Yan-Jiang Wang  1 , Xian-Le Bu  1
Affiliations

The Correlations of Plasma and Cerebrospinal Fluid Amyloid-Beta Levels with Platelet Count in Patients with Alzheimer's Disease

Hao-Lun Sun et al. Biomed Res Int. .

Abstract

Purpose: Recent study shows that blood-derived amyloid-beta (Aβ) can induce cerebral amyloidosis and is involved in the pathogenesis of Alzheimer's disease (AD). The vast majority of blood Aβ is generated from platelet. Whether blood Aβ levels are associated with the count of platelets remains unknown.

Methods: 58 clinically diagnosed AD patients, 18 11C-PIB-PET diagnosed AD patients, and 61 age- and gender-matched cognitively normal controls were included to analyze the correlation of plasma Aβ levels with platelet count. 13 AD patients and 40 controls with cerebrospinal fluid (CSF) samples were included to further analyze the correlation of CSF Aβ levels with platelet count. Aβ40 and Aβ42 levels in plasma and CSF were measured by ELISA kits.

Results: The plasma Aβ42 level was positively correlated with platelet count in both AD patients and control group, especially in AD patients with positive PIB-PET, while there was no correlation as to Aβ40. The CSF Aβ levels also had no significant correlation with platelet count.

Conclusion: It suggests that platelets may be involved in the pathogenesis of AD and become a potential peripheral biomarker for AD.

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Figures

Figure 1
Figure 1
Comparison of the plasma A β levels between the controls and patients with AD. ∗∗∗ denotes p< 0.001.
Figure 2
Figure 2
Correlations of plasma Aβ levels with platelet count in AD patients ((a) and (b)), normal controls ((c) and (d)), and all cases ((e) and (f)).
Figure 3
Figure 3
Correlation of plasma A β 42 levels with platelet count in AD patients with PiB-PET (+). ∗ denotes p< 0.05.
Figure 4
Figure 4
Correlations of CSF Aβ levels with platelet count in AD patients ((a) and (b)) and normal controls ((c) and (d)).
See this image and copyright information in PMC

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