Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Oct 11;3(Suppl Suppl 1):69-89.
doi: 10.1002/epi4.12261. eCollection 2018 Nov.

A companion to the preclinical common data elements for physiologic data in rodent epilepsy models. A report of the TASK3 Physiology Working Group of the ILAE/AES Joint Translational Task Force

Jan A Gorter  1 , Erwin A van Vliet  1   2 , Stefanie Dedeurwaerdere  3 , Gordon F Buchanan  4 , Daniel Friedman  5 , Karin Borges  6 , Heidi Grabenstatter  7 , Katarzyna Lukasiuk  8 , Helen E Scharfman  9 , Astrid Nehlig  10
Affiliations

A companion to the preclinical common data elements for physiologic data in rodent epilepsy models. A report of the TASK3 Physiology Working Group of the ILAE/AES Joint Translational Task Force

Jan A Gorter et al. Epilepsia Open. .

Abstract

The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force created the TASK3 working groups to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve standardization of experimental designs. This article concerns the parameters that can be measured to assess the physiologic condition of the animals that are used to study rodent models of epilepsy. Here we discuss CDEs for physiologic parameters measured in adult rats and mice such as general health status, temperature, cardiac and respiratory function, and blood constituents. We provide detailed CDE tables and case report forms (CRFs), and with this companion manuscript we discuss the monitoring of different aspects of physiology of the animals. The CDEs, CRFs, and companion paper are available to all researchers, and their use will benefit the harmonization and comparability of translational preclinical epilepsy research. The ultimate hope is to facilitate the development of biomarkers and new treatments for epilepsy.

Keywords: Common data elements; Epilepsy; Model; Physiology; Preclinical; Rodent.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Assessment of the general health status of adult rodent CRF module
Figure 2
Figure 2
Temperature CRF module
Figure 3
Figure 3
Respiration CRF module
Figure 4
Figure 4
Heart rate CRF module
Figure 5
Figure 5
Blood pressure CRF module
Figure 6
Figure 6
Comparison of blood collection methods
Figure 7
Figure 7
Blood testing CRF module
See this image and copyright information in PMC

References

    1. Smith DH, Hicks RR, Johnson VE, et al. Pre‐clinical traumatic brain injury common data elements: toward a common language across laboratories. J Neurotrauma 2015;32:1725–1735. - PMC - PubMed
    1. Lapinlampi N, Melin E, Aronica E, et al. Common data elements and data management: Remedy to cure underpowered preclinical studies. Epilepsy Res 2017;129:87–90. - PubMed
    1. Nehlig A, Pereira de Vasconcelos A, Boyet S. Quantitative autoradiographic measurement of local cerebral glucose utilization in freely moving rats during postnatal development. J Neurosci 1988;8:2321–2333. - PMC - PubMed
    1. Nehlig A, Pereira de Vasconcelos A. Glucose and ketone body utilization by the brain of neonatal rats. Prog Neurobiol 1993;40:163–221. - PubMed
    1. Hickman DL, Swan M. Use of a body condition score technique to assess health status in a rat model of polycystic kidney disease. J Am Assoc Lab Anim Sci 2010;49:155–159. - PMC - PubMed

LinkOut - more resources