Baclofen for the treatment of alcohol use disorder: the Cagliari Statement

Roberta Agabio¹, Julia Ma Sinclair², Giovanni Addolorato³, Henri-Jean Aubin⁴, Esther M Beraha⁵, Fabio Caputo⁶, Jonathan D Chick⁷, Patrick de La Selle⁸, Nicolas Franchitto⁹, James C Garbutt¹⁰, Paul S Haber¹¹, Mathis Heydtmann¹², Philippe Jaury¹³, Anne R Lingford-Hughes¹⁴, Kirsten C Morley¹⁵, Christian A Müller¹⁶, Lynn Owens¹⁷, Adam Pastor¹⁸, Louise M Paterson¹⁴, Fanny Pélissier¹⁹, Benjamin Rolland²⁰, Amanda Stafford²¹, Andrew Thompson¹⁷, Wim van den Brink²², Renaud de Beaurepaire²³, Lorenzo Leggio²⁴

Affiliations

¹ Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cittadella Universitaria, I-09042 Monserrato, Italy. Electronic address: agabio@unica.it.
² Faculty of Medicine, University of Southampton, Southampton, UK.
³ AUD and Alcohol Related Diseases Unit, Department of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy; Department of Internal Medicine and Gastroenterology, Università Cattolica del Sacro Cuore, Rome, Italy.
⁴ Centre de Recherche en Epidémiologie et Santé des Populations, Faculté de Médecine, Université Paris-Sud, Paris, France; Faculté de Médecine, Université de Versailles Saint-Quentin-en-Yvelines, Paris, France; Institut National de la Santé et de la Recherche Médicale, Université Paris-Saclay, Paris, France; Hôpitaux Universitaires Paris-Sud, Paris, France.
⁵ Department of Psychology, University of Amsterdam, Amsterdam, Netherlands.
⁶ SS Annunziata Hospital, Department of Internal Medicine, Cento, Italy.
⁷ Castle Craig Hospital, Blyth Bridge, UK; School of Health and Social Care, Edinburgh Napier University, Edinburgh, UK.
⁸ Montpellier 34000, France.
⁹ Department of Addiction Médicine, Poisons and Substance Abuse Treatment Centre, Toulouse-Purpan University Hospital, Toulouse, France.
¹⁰ Department of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
¹¹ National Health Medical Research Council, Centre of Research Excellence in Mental Health and Substance Use, Central Clinical School, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Drug Health Services, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
¹² Department of Gastroenterology, Royal Alexandra Hospital Paisley, Paisley, UK.
¹³ Département de Médecine Générale, Faculté de Médecine, Université Paris Descartes, Paris, France.
¹⁴ Neuropsychopharmacology Unit, Centre for Psychiatry, Division of Brain Sciences, Imperial College London, London, UK.
¹⁵ Discipline of Addiction Medicine, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
¹⁶ Department of Psychiatry, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany.
¹⁷ Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK.
¹⁸ Department of Addiction Medicine, St Vincent's Hospital Melbourne, Melbourne, Australia; Department of Medicine, University of Melbourne, Melbourne, Australia.
¹⁹ Poison Control Centre, Toulouse-Purpan University Hospital, Toulouse, France.
²⁰ Service Universitaire d'Addictologie de Lyon, Lyon, France; University of Lyon, Lyon, France.
²¹ Royal Perth Hospital, Perth, WA, Australia.
²² Department of Psychiatry, Amsterdam University Medical Centre, Academic Medical Centre, Amsterdam University, Amsterdam, Netherlands.
²³ Groupe Hospitalier Paul-Guiraud, Paris, France.
²⁴ Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Basic Research and National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Bethesda, MD, USA; Medication Development Program, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA; Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University, RI, USA.

PMID: 30413394
PMCID: PMC12440138
DOI: 10.1016/S2215-0366(18)30303-1

Comment

Baclofen for the treatment of alcohol use disorder: the Cagliari Statement

Roberta Agabio et al. Lancet Psychiatry. 2018 Dec.

. 2018 Dec;5(12):957-960.

doi: 10.1016/S2215-0366(18)30303-1. Epub 2018 Nov 6.

Authors

Affiliations

¹ Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cittadella Universitaria, I-09042 Monserrato, Italy. Electronic address: agabio@unica.it.
² Faculty of Medicine, University of Southampton, Southampton, UK.
³ AUD and Alcohol Related Diseases Unit, Department of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy; Department of Internal Medicine and Gastroenterology, Università Cattolica del Sacro Cuore, Rome, Italy.
⁴ Centre de Recherche en Epidémiologie et Santé des Populations, Faculté de Médecine, Université Paris-Sud, Paris, France; Faculté de Médecine, Université de Versailles Saint-Quentin-en-Yvelines, Paris, France; Institut National de la Santé et de la Recherche Médicale, Université Paris-Saclay, Paris, France; Hôpitaux Universitaires Paris-Sud, Paris, France.
⁵ Department of Psychology, University of Amsterdam, Amsterdam, Netherlands.
⁶ SS Annunziata Hospital, Department of Internal Medicine, Cento, Italy.
⁷ Castle Craig Hospital, Blyth Bridge, UK; School of Health and Social Care, Edinburgh Napier University, Edinburgh, UK.
⁸ Montpellier 34000, France.
⁹ Department of Addiction Médicine, Poisons and Substance Abuse Treatment Centre, Toulouse-Purpan University Hospital, Toulouse, France.
¹⁰ Department of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
¹¹ National Health Medical Research Council, Centre of Research Excellence in Mental Health and Substance Use, Central Clinical School, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Drug Health Services, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
¹² Department of Gastroenterology, Royal Alexandra Hospital Paisley, Paisley, UK.
¹³ Département de Médecine Générale, Faculté de Médecine, Université Paris Descartes, Paris, France.
¹⁴ Neuropsychopharmacology Unit, Centre for Psychiatry, Division of Brain Sciences, Imperial College London, London, UK.
¹⁵ Discipline of Addiction Medicine, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
¹⁶ Department of Psychiatry, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany.
¹⁷ Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK.
¹⁸ Department of Addiction Medicine, St Vincent's Hospital Melbourne, Melbourne, Australia; Department of Medicine, University of Melbourne, Melbourne, Australia.
¹⁹ Poison Control Centre, Toulouse-Purpan University Hospital, Toulouse, France.
²⁰ Service Universitaire d'Addictologie de Lyon, Lyon, France; University of Lyon, Lyon, France.
²¹ Royal Perth Hospital, Perth, WA, Australia.
²² Department of Psychiatry, Amsterdam University Medical Centre, Academic Medical Centre, Amsterdam University, Amsterdam, Netherlands.
²³ Groupe Hospitalier Paul-Guiraud, Paris, France.
²⁴ Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Basic Research and National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Bethesda, MD, USA; Medication Development Program, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA; Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University, RI, USA.

PMID: 30413394
PMCID: PMC12440138
DOI: 10.1016/S2215-0366(18)30303-1

No abstract available

PubMed Disclaimer

Comment in

Baclofen and alcohol in France.
Naudet F, Braillon A. Naudet F, et al. Lancet Psychiatry. 2018 Dec;5(12):961-962. doi: 10.1016/S2215-0366(18)30419-X. Epub 2018 Nov 6. Lancet Psychiatry. 2018. PMID: 30413392 No abstract available.

Comment on

Baclofen for alcohol use disorder-a systematic meta-analysis.
Bschor T, Henssler J, Müller M, Baethge C. Bschor T, et al. Acta Psychiatr Scand. 2018 Sep;138(3):232-242. doi: 10.1111/acps.12905. Epub 2018 Jun 10. Acta Psychiatr Scand. 2018. PMID: 29888478

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1. Roerecke M, Gual A, Rehm J. Reduction of alcohol consumption and subsequent mortality in alcohol use disorders: systematic review and meta-analyses. J Clin Psychiatry 2013; 74: e1181–89. - PubMed
1. Reus VI, Fochtmann LJ, Bukstein O, et al. The American Psychiatric Association practice guideline for the pharmacological treatment of patients with alcohol use disorder. Am J Psychiatry 2018; 175: 86–90. - PubMed
1. Soyka M, Kranzler HR, Hesselbrock V, Kasper S, Mutschler J, Möller HJ. WFSBP task force on treatment guidelines for substance use disorders. Guidelines for biological treatment of substance use and related disorders, part 1: alcoholism, first revision. World J Biol Psychiatry 2017; 18: 86–119. - PubMed

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Baclofen for the treatment of alcohol use disorder: the Cagliari Statement

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Baclofen for the treatment of alcohol use disorder: the Cagliari Statement

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