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Observational Study
. 2019 Feb;25(1):133-136.
doi: 10.1007/s13365-018-0689-2. Epub 2018 Nov 9.

Quantitative electroencephalography supports diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy

G Classen  1 , C Classen  2 , C Bernasconi  3 , C Brandt  4 , R Gold  5 , A Chan  5   6 , R Hoepner  7   8
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Free article
Observational Study

Quantitative electroencephalography supports diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy

G Classen et al. J Neurovirol. 2019 Feb.
Free article

Abstract

Long-term treatment of multiple sclerosis with natalizumab (NTZ) carries the risk of a devastating complication in the form of an encephalopathy caused by a reactivation of a latent John Cunningham virus infection (progressive multifocal leucoencephalopathy, PML). Early diagnosis is associated with considerably better prognosis. Quantitative EEG as an objective, rater-independent technique provides high sensitivity (88%) and specificity (82%) for the diagnosis of NTZ-PML. Combination of diagnostic modalities addressing static morphological (brain MRI) as well as functional (EEG) pathologic changes may improve risk management programmes.

Keywords: EEG; John Cunningham virus encephalopathy; Multiple sclerosis; Natalizumab; Pharmacovigilance; Screening.

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