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Review
. 2018 Dec;39(12):960-964.
doi: 10.1016/j.it.2018.10.008. Epub 2018 Nov 8.

Mechanisms of HLA-DP Antigen Processing and Presentation Revisited

Mark Anczurowski  1 , Naoto Hirano  2
Affiliations
Review

Mechanisms of HLA-DP Antigen Processing and Presentation Revisited

Mark Anczurowski et al. Trends Immunol. 2018 Dec.

Abstract

Polymorphisms in HLA-DP can modulate interactions with the invariant chain chaperone, contributing independently to differences in the peptide repertoire presented on DP. The resulting presentation of intracellular antigens directly to CD4+ T cells may partly explain genetic and clinical studies describing previously unexplained links between polymorphism in DP and disease.

Keywords: HLA Class II; HLA-DP; autoimmune disease; cancer; invariant chain; viral disease.

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