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Review
. 2018 Sep 7;14(12):1630-1635.
doi: 10.7150/ijbs.26932. eCollection 2018.

The Biological Roles of Translation Initiation Factor 3b

Xuefei Feng  1   2 , Juan Li  1   2 , Peijun Liu  1   2
Affiliations
Review

The Biological Roles of Translation Initiation Factor 3b

Xuefei Feng et al. Int J Biol Sci. .

Abstract

Translation has important roles in almost all physiological and pathological processes, and translation initiation factors are particularly relevant to the translation initiation step, which is the most important step in translation regulation. Translation initiation factor 3b (eIF3b), a key subunit of the largest translation initiation factor 3 (eIF3), is widely considered a scaffold protein that acts to ensure the accuracy of translation initiation. A series of recent finds has revealed that eIF3 is closely related to oncogenesis. However, the concrete mechanism by which eIF3b is involve in carcinogenesis remains elusive. Here, we summarize a series of research findings regarding the relationship between eIF3b, translation and cancer.

Keywords: cancer.; eIF3b; translation initiation.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Fig 1
Fig 1
The functions of eIF3.
Fig 2
Fig 2
Structure of YLC.
Fig 3
Fig 3
Domains of eIF3b protein in mammals and budding yeast.
Fig 4
Fig 4
The association of eIF3b and cancer.
See this image and copyright information in PMC

References

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