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. 2017 Jun:33:194-201.
doi: 10.1016/j.jff.2017.03.045. Epub 2017 Mar 29.

Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies

Kequan Zhou  1
Affiliations

Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies

Kequan Zhou. J Funct Foods. 2017 Jun.

Abstract

Akkermansia muciniphila is a mucin-degrading bacterium commonly found in human gut. A. muciniphila has been inversely associated with obesity, diabetes, inflammation, and metabolic disorders. Due to its highly promising probiotic activities against obesity and diabetes, A. muciniphila has drawn intensive interest for research and development in recent years. A number of human and animal studies have shown that the abundance of A. muciniphila in the gut can be enhanced through dietary interventions. The present review focuses on evidence-based dietary strategies of improving A. muciniphila abundance in the gut by critically appraising up-to-date available human and animal intervention studies on A. muciniphila growth and their impact on risk factors of obesity and diabetes. Their potential mechanisms in promoting A. muciniphila are also discussed along with the discussions of mechanism of action for A. muciniphila to exert probiotic functions.

Keywords: Akkermansia muciniphila; Diabetes; Dietary supplementation; Gut microbiota; Obesity; Probiotics.

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References

    1. Alard J, Lehrter V, Rhimi M, Mangin I, Peucelle V, Abraham AL, Grangette C. Beneficial metabolic effects of selected probiotics on diet-induced obesity and insulin resistance in mice are associated with improvement of dysbiotic gut microbiota. Environmental Microbiology. 2016;18(5):1484–1497. - PubMed
    1. Ambort D, Johansson MEV, Gustafsson JK, Nilsson HE, Ermund A, Johansson BR, Hansson GC. Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin. Proceedings of the National Academy of Sciences of the United States of America. 2012;109(15):5645–5650. - PMC - PubMed
    1. Anhê FF, Roy D, Pilon G, Dudonné S, Matamoros S, Varin TV, Marette A. A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice. Gut. 2015;64(6):872–883. - PubMed
    1. Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, Bork P. Enterotypes of the human gut microbiome. Nature. 2011;473(7346):174–180. - PMC - PubMed
    1. Atuma C, Strugala V, Allen A, Holm L. The adherent gastrointestinal mucus gel layer: Thickness and physical state in vivo. American Journal of Physiology - Gastrointestinal and Liver Physiology. 2001;280(5):G922–G929. - PubMed

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