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Case Reports
. 2018 Sep 3;10(9):e3244.
doi: 10.7759/cureus.3244.

A Rare Variant of Penile Squamous Cell Carcinoma in a Man with Paraplegia

Daniel C Morse  1 , Jaime A Tschen  2 , Sirunya Silapunt  3
Affiliations
Case Reports

A Rare Variant of Penile Squamous Cell Carcinoma in a Man with Paraplegia

Daniel C Morse et al. Cureus. .

Abstract

Verrucous carcinoma (VC) is a rare variant of squamous cell carcinoma (SCC). It is described as a low grade, slow growing, locally infiltrative neoplasm that accounts for 3%-8% of penile SCCs. Here we report a case of destructive VC of the glans penis in a paraplegic man resulting in a hypospadias from the tip of the glans to the corona. Histology demonstrated exophytic squamous epithelial proliferation with characteristic round, pushing borders. In situ hybridization was positive for both low-risk and high-risk strains of human papillomavirus.

Keywords: paraplegia; penile cancer; squamous cell carcinoma; verrucous; verrucous carcinoma.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. A 2.5-cm exophytic cauliflower-like penile nodule occupying the meatal orifice and ventral glans.
Figure 2
Figure 2. Low-power view of verrucous tumor with exophytic papillary architecture and a markedly irregular epidermal acanthosis (H&E, 10x).
Figure 3
Figure 3. Squamous epithelial proliferation with the characteristic blunt pushing deep margins (H&E, 20x).
Figure 4
Figure 4. Higher power magnification demonstrates nuclear polymorphism, mild cytologic atypia, and dyskeratosis with keratin pearls (H&E, 400x).
Figure 5
Figure 5. In situ hybridization of the lesion revealed strongly positive labeling of the nuclei with human papilloma virus (HPV) types 6 and 11.
Figure 6
Figure 6. Positive labeling of the nuclei with human papilloma virus (HPV) strains 31, 33 (in situ hybridization).
See this image and copyright information in PMC

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