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. 2018 Oct 17:2018:6804938.
doi: 10.1155/2018/6804938. eCollection 2018.

Low Hematocrit Is a Strong Predictor of Poor Prognosis in Lung Cancer Patients

Xin Zhang  1 , Fengmin Zhang  2 , Wenbo Qiao  1 , Xiansheng Zhang  3 , Zhefeng Zhao  4 , Mingqi Li  5
Affiliations

Low Hematocrit Is a Strong Predictor of Poor Prognosis in Lung Cancer Patients

Xin Zhang et al. Biomed Res Int. .

Abstract

Morbidity and mortality of lung cancer rank first in China and worldwide. Thus, noninvasive prognostic biomarkers are critical for clinicians to perform risk assessment in lung cancer patients prior to or during the course of treatment. In this study, we evaluated the prognostic value of preoperative hematocrit (HCT) count reduction on the long-term survival of lung cancer patients undergoing pneumonectomy and analyzed the correlation between reduced HCT counts and patients' clinicopathological features. A total of 1022 patients who underwent surgical treatment in Harbin Medical University Cancer Hospital, China, from February 2006 to December 2013, were enrolled in this study. The association between the clinicopathologic variables and HCT were evaluated by Mann-Whitney U-test and chi-square test, respectively. Survival curves were generated using Kaplan-Meier estimates, and differences between the curves were analyzed by a log-rank test. Multivariable analysis showed that high HCT (P < 0.001, HR: 0.595, 95% CI: 0.458-0.774) was favorable for patients' survival. Low HCT patients presented shorter mean months of OS than that of high HCT patients (P < 0.001). Male adenocarcinoma carcinoma patients with lower body mass index (BMI) and advanced tumor stage were more likely to observe low HCT. We identified for the first time reduced preoperative HCT count as an independent risk factor leading to poor prognosis in lung cancer patients who underwent surgical treatment.

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Figures

Figure 1
Figure 1
Prognostic value of the preoperative HCT in patients with lung cancer. (a) All patients with low HCT (n = 269) and high HCT (n = 753) (P < 0.001). (b) Squamous cell lung carcinoma patients with low HCT (n = 92) and high HCT (n = 177) (P = 0.281). (c) Lung adenocarcinoma patients with low HCT (n = 131) and high HCT (n = 462) (P < 0.001). (d) Younger patients with low HCT (n = 135) and high HCT (n = 429) (P = 0.030). (e) Older patients with low HCT (n = 134), and high HCT (n = 324) (P < 0.001). (f) Male patients with low HCT (n = 181) and high HCT (n = 409) (P < 0.001). (g) Female patients with low HCT (n = 88) and high HCT (n = 344) (P = 0.066).
Figure 2
Figure 2
Comparison of overall survival among 4 subgroups of lung adenocarcinoma cancer patients.
See this image and copyright information in PMC

References

    1. Kakimi K., Matsushita H., Murakawa T., Nakajima J. Lung cancer molecular epidemiology in China: recent trends. Translational Lung Cancer Research. 2014;3(1):23–33. doi: 10.3978/j.issn.2218-6751.2013.11.01. - DOI - PMC - PubMed
    1. Chen W. Cancer statistics: updated cancer burden in China. Chinese Journal of Cancer Research. 2015;27, article 1 - PMC - PubMed
    1. Xie X., Yao M., Chen X., et al. Reduced red blood cell count predicts poor survival after surgery in patients with primary liver cancer. Medicine (United States) 2015;94(8):p. e577. doi: 10.1097/MD.0000000000000577. - DOI - PMC - PubMed
    1. Ichinose J., Murakawa T., Kawashima M., et al. Prognostic significance of red cell distribution width in elderly patients undergoing resection for non-small cell lung cancer. Journal of Thoracic Disease. 2016;8(12):3658–3666. doi: 10.21037/jtd.2016.12.44. - DOI - PMC - PubMed
    1. Zhang F., Chen Z., Wang P., Hu X., Gao Y., He J. Combination of platelet count and mean platelet volume (COP-MPV) predicts postoperative prognosis in both resectable early and advanced stage esophageal squamous cell cancer patients. Tumor Biology. 2016;37(7):9323–9331. doi: 10.1007/s13277-015-4774-3. - DOI - PMC - PubMed