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Review
. 2018 Oct 23;3(4):229-235.
doi: 10.1016/j.synbio.2018.10.005. eCollection 2018 Dec.

Regulation of antibiotic biosynthesis in actinomycetes: Perspectives and challenges

Junhong Wei  1 , Lang He  2   3 , Guoqing Niu  2   3
Affiliations
Review

Regulation of antibiotic biosynthesis in actinomycetes: Perspectives and challenges

Junhong Wei et al. Synth Syst Biotechnol. .

Erratum in

  • Erratum regarding previously published articles.
    [No authors listed] [No authors listed] Synth Syst Biotechnol. 2020 Oct 12;5(4):328. doi: 10.1016/j.synbio.2020.10.003. eCollection 2020 Dec. Synth Syst Biotechnol. 2020. PMID: 33102826 Free PMC article.

Abstract

Actinomycetes are the main sources of antibiotics. The onset and level of production of each antibiotic is subject to complex control by multi-level regulators. These regulators exert their functions at hierarchical levels. At the lower level, cluster-situated regulators (CSRs) directly control the transcription of neighboring genes within the gene cluster. Higher-level pleiotropic and global regulators exert their functions mainly through modulating the transcription of CSRs. Advances in understanding of the regulation of antibiotic biosynthesis in actinomycetes have inspired us to engineer these regulators for strain improvement and antibiotic discovery.

Keywords: Actinomycetes; Antibiotic biosynthesis; Antibiotic discovery; Genetic manipulation; Regulation; Strain improvement.

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Figures

Fig. 1
Fig. 1
Cascade regulation of antibiotic biosynthesis. Schematic diagram showing the regulation of antibiotic biosynthesis mediated by cluster-situated regulators and pleiotropic or global regulators. The cluster-situated regulator R2 exert its regulatory function through activating biosynthetic genes within Cluster B. It can also repress the transcription of biosynthetic genes within Cluster A. The transcription of R2 can be activated by another cluster-situated regulator, which is encoded by the neighboring R1, and a global regulator situated outside of Cluster B. The transcription of R1 is controlled by a pleiotropic regulator situated outside of Cluster B.
See this image and copyright information in PMC

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