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. 2018 Nov;166(1):163-169.
doi: 10.1007/s10517-018-4306-4. Epub 2018 Nov 12.

Induction of Vasculo- and Osteogenesis in Spheroids Formed by Adipose-Derived Stromal Cells

I N Saburina  1   2 , A A Gorkun  1 , A F Fidarov  3 , T D Kolokol'tsova  4   5 , I M Zurina  1 , N V Kosheleva  1   2 , E E Ustinova  1 , V S Repin  1
Affiliations

Induction of Vasculo- and Osteogenesis in Spheroids Formed by Adipose-Derived Stromal Cells

I N Saburina et al. Bull Exp Biol Med. 2018 Nov.

Abstract

Vascularization of bioengineered bone tissue constructs remains a challenging problem of regenerative medicine. Spheroids generated in 3D culture of adipose-derived stromal cells supplemented with inducing factors demonstrate stable characteristics and express of mesenchymal, endothelial, and osteoblasts markers, and represent a prototype of vascularized microtissue. Adipose-derived stromal cells spheroids induced to both angio- and osteogenic differentiation can be used in development of new innovative technologies for in vitro fabrication of vascularized bioequivalents for repair of large bone defects.

Keywords: adipose-derived stromal cells; bioequivalent; osteogenesis; spheroid; vasculogenesis.

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