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Comment
. 2019 Apr;108(4):588-589.
doi: 10.1111/apa.14640. Epub 2018 Nov 28.

Major concerns about late hypothermia study

Lars Walløe  1 , Nils Lid Hjort  2 , Marianne Thoresen  1   3
Affiliations
Comment

Major concerns about late hypothermia study

Lars Walløe et al. Acta Paediatr. 2019 Apr.

Erratum in

  • Corrigendum.
    [No authors listed] [No authors listed] Acta Paediatr. 2019 Jul;108(7):1365. doi: 10.1111/apa.14843. Acta Paediatr. 2019. PMID: 31215082 Free PMC article. No abstract available.

Abstract

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Conflict of interest statement

The authors have no conflict of interests.

Figures

Figure 1
Figure 1
Confidence probability (y‐axis) for the relative risk parameter RR = (p1/p0) (x‐axis) points to the estimate 0.875 and provides confidence intervals at all levels of confidence probability. The 95% confidence interval is [0.51, 1.48] (broken horizontal line).
See this image and copyright information in PMC

Comment in

Comment on

References

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    1. Bourque SL, Dietz RM. Does late therapeutic hypothermia reduce risk of death or disability? Acta Paediatr 2018; 107: 1103. - PMC - PubMed
    1. Comet trial website https://clinicaltrials.gov/ct2/show/NCT03409770
    1. Gunn AJ, Bennet L, Gunning MI, Gluckman PD, Gunn TR. Cerebral hypothermia is not neuroprotective when started after postischemic seizures in fetal sheep. Pediatr Res 1999; 46: 274–80. - PubMed
    1. Sabir H, Scull‐Brown E, Liu X, Thoresen M. Immediate hypothermia is not neuroprotective after severe hypoxic‐ischemia and is deleterious when delayed by 12 hours in neonatal rats. Stroke 2012; 43: 3364–70. - PubMed

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