IL-1 Blockade Reduces Inflammation in Pulmonary Arterial Hypertension and Right Ventricular Failure: A Single-Arm, Open-Label, Phase IB/II Pilot Study
- PMID: 30418047
- PMCID: PMC6913087
- DOI: 10.1164/rccm.201809-1631LE
IL-1 Blockade Reduces Inflammation in Pulmonary Arterial Hypertension and Right Ventricular Failure: A Single-Arm, Open-Label, Phase IB/II Pilot Study
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Comment in
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Anakinra, What Is Thy Bidding in Pulmonary Hypertension?Am J Respir Crit Care Med. 2019 Feb 1;199(3):267-269. doi: 10.1164/rccm.201811-2192ED. Am J Respir Crit Care Med. 2019. PMID: 30540501 No abstract available.
References
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- Soon E, Holmes AM, Treacy CM, Doughty NJ, Southgate L, Machado RD, et al. Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension. Circulation. 2010;122:920–927. - PubMed
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- Voelkel NF, Tuder RM, Bridges J, Arend WP. Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline. Am J Respir Cell Mol Biol. 1994;11:664–675. - PubMed
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