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. 2018 Nov 12;18(1):558.
doi: 10.1186/s12879-018-3487-9.

Persistent candidemia in very low birth weight neonates: risk factors and clinical significance

Jinjian Fu  1 , Yanling Ding  2 , Yongjiang Jiang  3 , Shengfu Mo  2 , Shaolin Xu  2 , Peixu Qin  2
Affiliations

Persistent candidemia in very low birth weight neonates: risk factors and clinical significance

Jinjian Fu et al. BMC Infect Dis. .

Abstract

Background: The prevalence and risk factors for persistent candidemia among very low birth weight infants are poorly understood. This study aimed to investigate the epidemiology of persistent candidemia over a 4-year period in a neonatal intensive care unit (NICU) in Liuzhou, China.

Methods: We retrospectively extracted demographic data, risk factors, microbiological results and outcomes of very low birth weight infants with candidemia in our hospital between January 2012 and November 2015. Persistent candidemia was defined as a positive blood culture for > 5 days. Logistic regression was used to identify risk factors associated with persistent candidemia.

Results: Of 48 neonates with candidemia, 28 had persistent candidemia. Both mechanical ventilation and intubation were significantly associated with increased rates of persistent candidemia (P = 0.044 and 0.004, respectively). The case fatality rate for the persistent candidemia group was 14.3%.

Conclusion: The rate of persistent candidemia was high among very low birth weight neonates. Mechanical ventilation and intubation were the major factors associated with the development of persistent candidemia. This study highlights the importance of intensive prevention and effective treatment among neonates with persistent candidemia.

Keywords: Epidemiology; Neonates; Persistent candidemia; Very low birth weight.

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Conflict of interest statement

Ethics approval and consent to participate

This study was approved by the Institutional Review Board of Liuzhou Maternity and Child Healthcare Hospital, and further permission was obtained from hospital to review the patient medical records.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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