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Case Reports
. 2018 Nov 12;16(1):221.
doi: 10.1186/s12957-018-1520-5.

Dedifferentiated liposarcoma of the gallbladder: first reported case

Adriano Carneiro da Costa  1 , Fernando Santa-Cruz  2 , Brena F Sena  3 , Ademar Lopes  4 , Nicole Leite  5 , Alexandre Rolim da Paz  6 , Álvaro A B Ferraz  7 , José-Luiz Figueiredo  7
Affiliations
Case Reports

Dedifferentiated liposarcoma of the gallbladder: first reported case

Adriano Carneiro da Costa et al. World J Surg Oncol. .

Abstract

Background: Liposarcoma of the gallbladder is an extremely rare sarcoma, with only five cases reported in the literature according to our knowledge.

Case presentation: A 71-year-old woman was referred to the Surgical Oncology Division of Napoleão Laureano Hospital (João Pessoa, PB, Brazil) due to a solid mass at the right side of the abdomen and fever, with no signs of jaundice. Abdominal ultrasonography and computed tomography (CT) evidenced an extensive gallbladder lobular formation adhered to the inferior border of the right hepatic lobe and cholelithiasis. The CT report suggested gallbladder liposarcoma. A cholecystectomy associated with resection of segments IV-B and V of the liver were performed. Intraoperative frozen sections were compatible with gallbladder sarcoma. Anatomopathological examination and immunohistochemistry confirmed dedifferentiated liposarcoma with foci of heterologous leiomyosarcomatous differentiation and undifferentiated fusocellular areas of high histological grade.

Conclusion: This is the first case of dedifferentiated liposarcoma of the gallbladder to be reported.

Keywords: Dedifferentiated liposarcoma; Gallbladder disease; Gallbladder neoplasms; Immunohistochemistry; Liposarcoma.

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Conflict of interest statement

Ethics approval and consent to participate

Not applicable.

Consent for publication

The patient provided written consent to publish this case report.

Competing interests

The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
Preoperative CT scans: coronal section of non-enhanced CT image showing a large mass adhered to the liver, pushing the transverse colon down (a). Transverse section imaging showing three large gallbladder stones without (b) and with (c) CT contrast enhancement
Fig. 2
Fig. 2
Gallbladder tumor adhered to the right hepatic lobe (a). Peritoneum and common biliary duct without tumor invasion (b). Gallbladder tumor resected with segments IV-B and V of the liver (c). Opened excised tumor with areas of coagulative necrosis and cholelithiasis (d)
Fig. 3
Fig. 3
Dedifferentiated liposarcoma of the gallbladder stained with hematoxylin and eosin (H&E) (a). Foci of heterologous leiomyosarcomatous differentiation with immunohistochemical (IHC) staining for S100 Protein (b) and undifferentiated fusocellular areas of high histological grade with IHC staining for desmin (c)
Fig. 4
Fig. 4
Postoperative CT scans: transverse section imaging showing no signs of recurrence 8 months after surgery
See this image and copyright information in PMC

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