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Review
. 2018 Oct 29:9:2480.
doi: 10.3389/fimmu.2018.02480. eCollection 2018.

Targeting Chemokines and Chemokine Receptors in Melanoma and Other Cancers

Nicolas Jacquelot  1   2 , Connie P M Duong  3   4 , Gabrielle T Belz  1   2 , Laurence Zitvogel  3   4   5   6
Affiliations
Review

Targeting Chemokines and Chemokine Receptors in Melanoma and Other Cancers

Nicolas Jacquelot et al. Front Immunol. .

Abstract

The tumor microenvironment is highly heterogeneous. It is composed of a diverse array of immune cells that are recruited continuously into lesions. They are guided into the tumor through interactions between chemokines and their receptors. A variety of chemokine receptors are expressed on the surface of both tumor and immune cells rendering them sensitive to multiple stimuli that can subsequently influence their migration and function. These features significantly impact tumor fate and are critical in melanoma control and progression. Indeed, particular chemokine receptors expressed on tumor and immune cells are strongly associated with patient prognosis. Thus, potential targeting of chemokine receptors is highly attractive as a means to quench or eliminate unconstrained tumor cell growth.

Keywords: cell migration; chemokine; chemokine receptor; immune cell trafficking; melanoma.

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Figures

Figure 1
Figure 1
Chemokine receptors and their corresponding ligands. Chemokine receptors (red) influence melanoma tumor cell migration/invasion or immune cell trafficking to the tumor lesions. The chemokine receptor associated color code is conserved between Figures 1, 2. Images were taken from Servier Medical Art (https://smart.servier.com) and modified by the authors under the following terms: Creative Commons Attribution 3.0 Unported License.
Figure 2
Figure 2
Organ-specific melanoma metastases according to tissue/melanoma specific chemokine/chemokine receptor expression. Images were taken from Servier Medical Art (https://smart.servier.com) and modified by the authors under the following terms: Creative Commons Attribution 3.0 Unported License.
See this image and copyright information in PMC

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