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. 2019 May;64(2):246-253.
doi: 10.1007/s12020-018-1812-0. Epub 2018 Nov 12.

Quality of life assessment in patients with HNF1A-MODY and GCK-MODY

Magdalena Szopa  1   2 , Bartlomiej Matejko  1   2 , Damian Ucieklak  1   2 , Agata Uchman  1 , Jerzy Hohendorff  1   2 , Sandra Mrozińska  1   2 , Wojciech Głodzik  3 , Barbara Zapała  4 , Teresa Płatek  4 , Iwona Solecka  2 , Cyrus M Sani  1 , Maciej T Małecki  5   6
Affiliations

Quality of life assessment in patients with HNF1A-MODY and GCK-MODY

Magdalena Szopa et al. Endocrine. 2019 May.

Abstract

Aim: The impact of maturity onset diabetes of the young (MODY) on quality of life (QoL) has never been examined. We assessed disease impact on QoL among patients with HNF1A-MODY and GCK mutation carrier status.

Methods: The study included 80 patients with HNF1A-MODY and 89 GCK gene mutation carriers. We also examined 128 type 1 diabetes (T1DM) patients for comparison. Diabetes-specific QoL was assessed using the Audit of Diabetes Dependent Quality of Life questionnaire.

Results: HNF1A-MODY and GCK-MODY groups had similar mean age (41.7 vs. 38.0 years, respectively) and BMI (24.1 vs. 24.3 kg/m2), whereas T1DM patients were on average younger (34.2 years) with similar BMI (25.0 kg/m2). Less than a third of GCK mutation carriers were on pharmacotherapy (n = 20, 31%), while the majority of HNF1A mutation carriers used oral drugs or insulin (n = 66, 82.5%). While current QoL was similar across the three groups (p = 0.66), two other major indices-the impact of diabetes on QoL and the average weighted impact (AWI)-differed among them (p < 0.001 for both comparisons). The impact of diabetes on patient QoL and AWI observed in both MODY groups was smaller than in T1DM. Etiological diagnosis of diabetes and a diagnosis of retinopathy were the only independent factors influencing the impact of diabetes on QoL and AWI in regression analysis. In HNF1A-MODY, all three major indices of QoL were more heavily influenced for patients on insulin in comparison to other treatment sub-groups.

Conclusion: MODY has a smaller negative impact on QoL compared to T1DM. Mode of treatment further stratifies QoL decline for HNF1A-MODY subjects.

Keywords: Diabetes; MODY; Quality of life.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Diabetes mean impact on QoL in patients with HNF1A-MODY, GCK-MODY, and T1DM
Fig. 2
Fig. 2
Diabetes mean impact on specific domains of QoL in patients with HNF1A-MODY GCK-MODY and T1DM
Fig. 3
Fig. 3
Diabetes mean impact on specific domains of QoL in patients with HNF1A-MODY compared to T1DM
Fig. 4
Fig. 4
Diabetes mean impact on specific domains of QoL in patients with HNF1A-MODY according to treatment method
See this image and copyright information in PMC

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