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Book

Tranexamic Acid

John M. Chauncey  1 , Preeti Patel
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Free Books & Documents
Book

Tranexamic Acid

John M. Chauncey et al.
Free Books & Documents

Excerpt

Tranexamic acid (TXA) is approved by the FDA for managing heavy menstrual bleeding and for short-term use in patients with hemophilia, including the prevention of bleeding during dental procedures and the treatment of menorrhagia. Off-label use extends to trauma settings, including massive transfusion protocols and combat injuries requiring blood transfusion within 24 hours, as well as surgical procedures to reduce intraoperative blood loss. TXA may be administered orally, topically, or intravenously, with the route of administration depending on the clinical context and severity of bleeding.

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Conflict of interest statement

Disclosure: John Chauncey declares no relevant financial relationships with ineligible companies.

Disclosure: Preeti Patel declares no relevant financial relationships with ineligible companies.

References

    1. Wardrop D, Estcourt LJ, Brunskill SJ, Doree C, Trivella M, Stanworth S, Murphy MF. Antifibrinolytics (lysine analogues) for the prevention of bleeding in patients with haematological disorders. Cochrane Database Syst Rev. 2013 Jul 29;(7):CD009733. - PubMed
    1. Watterson C, Beacher N. Preventing perioperative bleeding in patients with inherited bleeding disorders. Evid Based Dent. 2017 Mar;18(1):28-29. - PubMed
    1. Srinil S, Jaisamrarn U. Treatment of idiopathic menorrhagia with tranexamic acid. J Med Assoc Thai. 2005 Oct;88 Suppl 2:S1-6. - PubMed
    1. CRASH-2 trial collaborators. Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, Hunt B, Iribhogbe P, Izurieta M, Khamis H, Komolafe E, Marrero MA, Mejía-Mantilla J, Miranda J, Morales C, Olaomi O, Olldashi F, Perel P, Peto R, Ramana PV, Ravi RR, Yutthakasemsunt S. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 2010 Jul 03;376(9734):23-32. - PubMed
    1. CRASH-2 collaborators. Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt BJ, Morales C, Perel P, Prieto-Merino D, Woolley T. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet. 2011 Mar 26;377(9771):1096-101, 1101.e1-2. - PubMed

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