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Comment
. 2018 Nov 12;34(5):695-696.
doi: 10.1016/j.ccell.2018.10.012.

Metabolic Flexibility in Leukemia-Adapt or Die

Boaz Nachmias  1 , Aaron D Schimmer  2
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Metabolic Flexibility in Leukemia-Adapt or Die

Boaz Nachmias et al. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Jones et al. demonstrate that LSCs are metabolically inflexible. LSCs rely on amino acid metabolism to fuel oxidative phosphorylation and cannot compensate with other fuel sources following amino acid depletion. Combined venetoclax and azacitidine reduces amino acid uptake, partly explaining the anti-LSC effects.

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