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Review
. 2018 Nov 9;19(11):3533.
doi: 10.3390/ijms19113533.

Anticancer Activity of Natural Compounds from Plant and Marine Environment

Anna Lichota  1 , Krzysztof Gwozdzinski  2
Affiliations
Review

Anticancer Activity of Natural Compounds from Plant and Marine Environment

Anna Lichota et al. Int J Mol Sci. .

Abstract

This paper describes the substances of plant and marine origin that have anticancer properties. The chemical structure of the molecules of these substances, their properties, mechanisms of action, their structure⁻activity relationships, along with their anticancer properties and their potential as chemotherapeutic drugs are discussed in this paper. This paper presents natural substances from plants, animals, and their aquatic environments. These substances include the vinca alkaloids, mistletoe plant extracts, podophyllotoxin derivatives, taxanes, camptothecin, combretastatin, and others including geniposide, colchicine, artesunate, homoharringtonine, salvicine, ellipticine, roscovitine, maytanasin, tapsigargin, and bruceantin. Compounds (psammaplin, didemnin, dolastin, ecteinascidin, and halichondrin) isolated from the marine plants and animals such as microalgae, cyanobacteria, heterotrophic bacteria, invertebrates (e.g., sponges, tunicates, and soft corals) as well as certain other substances that have been tested on cells and experimental animals and used in human chemotherapy.

Keywords: anticancer properties; natural compounds; substances from marin.

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Conflict of interest statement

The authors declare no conflict of interest. We confirm all figures and tables in your manuscript are non-published and original.

Figures

Figure 1
Figure 1
Catharanthus alkaloids: (1) vincristine, (2) vinblastine, (3) vindesine, (4) vinorelbine, and (5) vinflunine.
Figure 2
Figure 2
Taxanes: (6) paclitaxel, (7) docetaxel, (8) cabazitaxel.
Figure 3
Figure 3
Camptothecin and its derivatives: (9) camptothecin, (10) irinotecan, (11) topotecan.
Figure 4
Figure 4
(12) Hydrolysis of the lactone ring in camptothecin.
Figure 5
Figure 5
Stabilizing of the E ring by addition of methylene group; (13) diflomotecan.
Figure 6
Figure 6
Stabilizing of the E ring by withdrawing of the lactonic group; (14) derivative of campothecin with the methylenodioxy ring and the substituent cyclobutane at position 7.
Figure 7
Figure 7
Camptothecin complex with topoisomerase I and DNA base [41].
Figure 8
Figure 8
(15) Exatecan.
Figure 9
Figure 9
(16) Combretastatin A-1.
Figure 10
Figure 10
Pelatins: (17) α-peltatin, (18) β-peltatin.
Figure 11
Figure 11
Podophyllotoxin derivatives: (19) podophyllotoxin, (20) etoposide, (21) teniposide.
Figure 12
Figure 12
Genipin derivatives: (22) genipin, (23) geniposide, (24) geniposidic acid.
Figure 13
Figure 13
(25) Colchicine.
Figure 14
Figure 14
(26) Artesunate.
Figure 15
Figure 15
(27) Homoharrigtonine.
Figure 16
Figure 16
(28) Salvicine.
Figure 17
Figure 17
(29) Ellipticine.
Figure 18
Figure 18
(30) Roscovitine.
Figure 19
Figure 19
(31) Maytansin.
Figure 20
Figure 20
(32) Thapsigargin.
Figure 21
Figure 21
(33) Bruceantin.
Figure 22
Figure 22
Psammaplin derivatives: (34) psammaplin A, (35) psammaplin F, (36) psammaplin G, (37) biprasin.
Figure 23
Figure 23
(38) NVP-LAQ824.
Figure 24
Figure 24
(39) Didemnin B, (40) plitidepsin.
Figure 25
Figure 25
Dolastin 10 and dolastin 15 derivatives: (41) dolastatin 10, (42) auristatin PE, (43) cematodin, (44) synthadotin, (45) dolastatin 15.
Figure 26
Figure 26
(46) Ecteinascidin, (47) cyanosafracin B.
Figure 27
Figure 27
(48) Halichondrin B, (49) halichondrin analog E7389.
See this image and copyright information in PMC

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