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. 2018 Oct 24:11:7277-7293.
doi: 10.2147/OTT.S177768. eCollection 2018.

Efficacy and safety analysis on dendritic cell-based vaccine-treated high-grade glioma patients: a systematic review and meta-analysis

Changling Li  1 , Ting Liu  2 , Bo Zhou  3 , Yubin Zhou  4 , Huiying Yu  1 , Yun Sun  2
Affiliations

Efficacy and safety analysis on dendritic cell-based vaccine-treated high-grade glioma patients: a systematic review and meta-analysis

Changling Li et al. Onco Targets Ther. .

Abstract

Background: Dendritic cell (DC)-based vaccine is a promising therapy for high-grade gliomas (HGGs); however, its actual effectiveness still remains controversial. This meta-analysis aims to extensively evaluate the efficacy and safety of DC vaccine for HGG patients.

Methods: We systematically searched PubMed, the Cochrane Library, EMBASE, Medline, and Web of Science for relevant parallel randomized controlled trials (RCTs) and properly controlled non-randomized studies (NRS) published in English. Two investigators reviewed all the texts and extracted information regarding overall survival (OS), progression-free survival (PFS), and adverse events (AEs) from eligible studies. Sensitivity analyses and subgroup analyses were also conducted.

Results: Of 353 suitable studies, 13 studies (three RCTs and ten NRS) involving 944 patients were finally included. Compared to the control therapy group (CT group), the DC group showed better OS and PFS without serious AEs. Subgroup analysis showed that trials designed as NRS obtained better results in the DC group in this study; however, no specific subgroup regarding dosages, cycles or injection routes was found to be superior in the DC group compared to the CT group.

Conclusion: DC vaccine can significantly improve OS and PFS, with acceptable toxicity, of HGG patients. Nevertheless, further studies are needed to verify this conclusion.

Keywords: dendritic cell; glioblastoma multiforme; high-grade gliomas; overall survival; progression-free survival; vaccine.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Study selection process.
Figure 2
Figure 2
Risk of bias analysis for randomized clinical trials included.
Figure 3
Figure 3
Sensitivity analysis for 1-year overall survival.
Figure 4
Figure 4
Publication bias analysis for 1-year overall survival.
See this image and copyright information in PMC

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