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Clinical Trial
. 1988;8(3):189-97.

Randomized double-blind study of flunarizine versus placebo in patients with chronic cerebrovascular disorders

A Agnoli  1 , V Manna, N Martucci, M Fioravanti, F Ferromilone, A Cananzi, G D'Andrea, A De Rosa, R Vizioli, E Sinforiani, et al.
Affiliations
  • PMID: 3042644
Clinical Trial

Randomized double-blind study of flunarizine versus placebo in patients with chronic cerebrovascular disorders

A Agnoli et al. Int J Clin Pharmacol Res. 1988.

Abstract

Chronic cerebrovascular disorders (CCVD), as defined by the 1980 Ad Hoc Committee in Paris, constitute both clinically and pathogenetically an extremely complex entity, characterized by a protean symptom pattern. The effects of a daily dose of 10 mg flunarizine orally on CCVD have been evaluated with a neuropsychological methodology during a three-month treatment period in a randomized double-blind study compared with a placebo. The results confirmed the effectiveness of the drug in the improvement of neurological, amnesic, attentive and behavioural symptoms, without evident side-effects even after a long-term treatment.

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