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. 2019 Apr;62(4):310-319.
doi: 10.1111/myc.12869. Epub 2019 Jan 22.

Developing definitions for invasive fungal diseases in critically ill adult patients in intensive care units. Protocol of the FUNgal infections Definitions in ICU patients (FUNDICU) project

Matteo Bassetti  1 , Luigia Scudeller  2 , Daniele R Giacobbe  3   4 , Frederic Lamoth  5   6 , Elda Righi  1 , Valentina Zuccaro  2 , Cecilia Grecchi  2 , Chiara Rebuffi  2 , Murat Akova  7 , Ana Alastruey-Izquierdo  8 , Sevtap Arikan-Akdagli  9 , Elie Azoulay  10 , Stijn I Blot  11 , Oliver A Cornely  12 , Cornelia Lass-Flörl  13 , Philipp Koehler  12 , Manuel Cuenca-Estrella  8 , Dylan W de Lange  14 , Francesco G De Rosa  15 , Jan J De Waele  16 , George Dimopoulos  17 , José Garnacho-Montero  18 , Martin Hoenigl  19   20 , Souha S Kanj  21 , Johan Maertens  22 , Ignacio Martin-Loeches  23 , Patricia Muñoz  24   25 , Bart J Kullberg  26 , Christina Agvald-Ohman  27 , Garyphallia Poulakou  28 , Jordi Rello  29 , Maurizio Sanguinetti  30 , Fabio S Taccone  31 , Jean-François Timsit  32   33 , Antoni Torres  34 , Jose A Vazquez  35 , Thierry Calandra  5 ; from the Study Group for Infections in Critically Ill Patients (ESGCIP) and the Fungal Infection Study Group (EFISG) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID); European Society of Intensive Care Medicine (ESICM); European Confederation of Medical Mycology (ECMM); Mycoses Study Group Education and Research Consortium (MSGERC)
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Free article

Developing definitions for invasive fungal diseases in critically ill adult patients in intensive care units. Protocol of the FUNgal infections Definitions in ICU patients (FUNDICU) project

Matteo Bassetti et al. Mycoses. 2019 Apr.
Free article

Abstract

Background: The reliability of diagnostic criteria for invasive fungal diseases (IFD) developed for severely immunocompromised patients is questionable in critically ill adult patients in intensive care units (ICU).

Objectives: To develop a standard set of definitions for IFD in critically ill adult patients in ICU.

Methods: Based on a systematic literature review, a list of potential definitions to be applied to ICU patients will be developed by the ESCMID Study Group for Infections in Critically Ill Patients (ESGCIP) and the ESCMID Fungal Infection Study Group (EFISG) chairpersons. The proposed definitions will be evaluated by a panel of 30 experts using the RAND/UCLA appropriateness methods. The panel will rank each of the proposed definitions on a 1-9 scale trough a dedicated questionnaire, in two rounds: one remote and one face-to-face. Based on their median rank and the level of agreement across panel members, selected definitions will be organised in a main consensus document and in an executive summary. The executive summary will be made available online for public comments.

Conclusions: The present consensus project will seek to provide standard definitions for IFD in critically ill adult patients in ICU, with the ultimate aims of improving their clinical outcome and facilitating the comparison and generalizability of research findings.

Keywords: Aspergillus; Candida; biomarker; candidiasis; cryptococcosis; diagnosis; pneumocystosis.

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