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. 2019 Feb 13;17(7):1763-1766.
doi: 10.1039/c8ob02575d.

Chiral selenide-catalyzed enantioselective synthesis of trifluoromethylthiolated 2,5-disubstituted oxazolines

Tian Qin  1 , Quanbin Jiang, Jieying Ji, Jie Luo, Xiaodan Zhao
Affiliations

Chiral selenide-catalyzed enantioselective synthesis of trifluoromethylthiolated 2,5-disubstituted oxazolines

Tian Qin et al. Org Biomol Chem. .

Abstract

Chiral selenide-catalyzed enantioselective trifluoromethylthiolation of 1,1-disubstituted alkenes is disclosed. By this method, a variety of chiral trifluoromethylthiolated 2,5-disubstituted oxazolines were obtained in good yields with high enantioselectivities. This work not only provides a new pathway for the synthesis of chiral oxazolines, but also expands the library of chiral trifluoromethylthiolated molecules.

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