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. 1988 Aug;170(8):3485-92.
doi: 10.1128/jb.170.8.3485-3492.1988.

In vivo studies of repair of 2-aminopurine in Escherichia coli

R H Grafstrom  1 , A Amsterdam, K Zachariasewycz
Affiliations

In vivo studies of repair of 2-aminopurine in Escherichia coli

R H Grafstrom et al. J Bacteriol. 1988 Aug.

Abstract

The repair of the base analog 2-aminopurine has been studied in vivo by using a temperature-sensitive mutant of the cloned mutH gene of Escherichia coli. Our results suggest that the lethal event in killing of dam mutants by 2-aminopurine does not result simply from incorporation of 2-aminopurine into the DNA and its subsequent repair. Furthermore, a 10-fold increase in the level of 2-aminopurine incorporated into the DNA of a dam mutH double mutant has little effect on the mutation frequency of this strain. An alternative mechanism for the mutagenicity of 2-aminopurine in E. coli is proposed.

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