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. 2018;25(4):201-205.
doi: 10.1159/000494435. Epub 2018 Nov 14.

CXCL12 and CXCR4 in the Peripheral Blood of Patients with Parkinson's Disease

Vahid Bagheri  1 , Hossein Khorramdelazad  1 , Gholamhossein Hassanshahi  1 , Amir Moghadam-Ahmadi  2   3 , Alireza Vakilian  4   5
Affiliations

CXCL12 and CXCR4 in the Peripheral Blood of Patients with Parkinson's Disease

Vahid Bagheri et al. Neuroimmunomodulation. 2018.

Abstract

Objective: The role of CXCL12 and its receptor CXCR4 has not been fully examined in Parkinson's disease (PD). The purpose of this study was to investigate the role of CXCL12/CXCR4 in the peripheral blood of patients with PD and healthy controls.

Methods: CXCL12 serum levels and CXCR4 mRNA levels were measured in 30 PD patients and 40 controls using ELISA and real-time PCR, respectively.

Results: CXCL12 serum levels were significantly higher in PD patients compared to controls (p < 0.0001). Moreover, CXCR4 expression in peripheral blood mononuclear cells (PBMC) of PD patients was significantly increased compared to controls (p < 0.0001).

Conclusions: Our findings provide new information on the expression of CXCL12/CXCR4 in PD. CXCR4 expression in PBMC or CXCL12 serum levels may be potential biomarkers of inflammation in PD patients.

Keywords: CXCL12; CXCR4; Chemokine; Neuroinflammation; Parkinson’s disease.

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