Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Nov 27;115(48):12086-12088.
doi: 10.1073/pnas.1817562115. Epub 2018 Nov 14.

"Fragile" equilibrium between translation and transcription

Wayne S Sossin  1
Affiliations
Comment

"Fragile" equilibrium between translation and transcription

Wayne S Sossin. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Schematic for how loss of FMRP leads to changes in mRNA levels. (A) Sites in the mRNA (yellow bar) that bind to RBP link to the RNA degradation machinery, leading to RNA degradation. FMRP stabilizes mRNAs by competing for these sites. (B) FMRP assists in miRNA loading, leading to RNA degradation of the mRNAs targeted by that miRNA. Alternatively, FMRP binding to mRNA can prevent miRNA binding and stabilize mRNAs. (C) FMRP normally translationally represses both transcriptional activators and transcriptional repressors. Loss of FMRP increases levels of these proteins, leading to transcriptional changes. (D) FMRP increases ribosome loading on a subset of mRNAs. If these mRNAs are part of a complex, the altered stoichiometry of the complex may lead to unfolded nascent chains, ribosome stalling, and degradation of the mRNAs. RISC, RNA-induced silencing complex.
See this image and copyright information in PMC

Comment on

References

    1. Garber KB, Visootsak J, Warren ST. Fragile X syndrome. Eur J Hum Genet. 2008;16:666–672. - PMC - PubMed
    1. Banerjee A, Ifrim MF, Valdez AN, Raj N, Bassell GJ. Aberrant RNA translation in fragile X syndrome: From FMRP mechanisms to emerging therapeutic strategies. Brain Res. 2018;1693:24–36. - PMC - PubMed
    1. Luo Y, et al. Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. PLoS Genet. 2010;6:e1000898. - PMC - PubMed
    1. Liu B, et al. Regulatory discrimination of mRNAs by FMRP controls mouse adult neural stem cell differentiation. Proc Natl Acad Sci USA. 2018;115:E11397–E11405. - PMC - PubMed
    1. Gerstberger S, Hafner M, Tuschl T. A census of human RNA-binding proteins. Nat Rev Genet. 2014;15:829–845. - PMC - PubMed

Substances

LinkOut - more resources