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. 2018 Oct;35(5):495-497.
doi: 10.5114/ada.2018.77241. Epub 2018 Jul 19.

Omalizumab improves forced expiratory volume in 1 second in patients with severe asthma

Krzysztof Pałgan  1 , Magdalena Żbikowska-Götz  1 , Kinga Lis  1 , Elżbieta Chrzaniecka  1 , Zbigniew Bartuzi  1
Affiliations

Omalizumab improves forced expiratory volume in 1 second in patients with severe asthma

Krzysztof Pałgan et al. Postepy Dermatol Alergol. 2018 Oct.

Abstract

Introduction: Asthma is a multiphenotypic disease, and therapeutic managenment in patients with severe asthma is particulary difficult, with conventional treatment of severe asthma showing poor efficacy.

Aim: To analyse forced expiratory volume in 1 s (FEV1) following the adminstration of omalizumab.

Material and methods: Six patinents (mean age: 50 ±12.6) with severe, uncontrolled asthma according to the GINA guidelines were enrolled in the study.

Results: Treatment with omalizumab increased in all subjects FEV1 by 17.28 ±13.4% after months and 18.57 ±13.4% after 12 months of treatment.

Conclusions: These results provides further evidence that therapy with omalizumab improves spiromtric parameters in severe asthma.

Keywords: asthma; forced expiratory volume in 1 s; omalizumab; spirometry.

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Figures

Figure 1
Figure 1
Total IgE levels in patients prior to omalizumab enrolment
Figure 2
Figure 2
Effects of omalizumab therapy on FEV1
Figure 3
Figure 3
Increase in FEV1 in patients treated with omalizumab
See this image and copyright information in PMC

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References

    1. Global Initiative for Asthma (GINA) National Heart, Lung and Blood Institute (NHLBI) Global strategy for asthma management and prevention Bethesda (MD): Global Initiative for Asthma (GINA), National Heart, Lung and Blood Institute (NHLBI) 2006. Available from: www.ginasthma.com.
    1. Raoufy MR, Ghafari T, Darooei R, et al. Classification of asthma based on nonlinear analysis of breathing pattern. PLoS One. 2016;11:e0147976. - PMC - PubMed
    1. Busse W, Corren J, Lanier BQ, et al. Omalizumab, antiIgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma. J Allergy Clin Immunol. 2001;108:184–90. - PubMed
    1. Kupryś-Lipińska I, Majak P, Molinska J, Kuna P. Effectiveness of the Polish program for the treatment of severe allergic asthma with omalizumab: a single-center experience. BMC Pulm Med. 2016;16:61. - PMC - PubMed
    1. Lai T, Wang S, Xu Z, et al. Long-term efficacy and safety of omalizumab in patients with persistent uncontrolled allergic asthma: a systematic review and meta-analysis. Sci Rep. 2015;5:8191. - PMC - PubMed