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Review
. 2018 Nov;6(4):257-262.
doi: 10.1093/gastro/goy025. Epub 2018 Jul 24.

Management of chronic hepatitis B during pregnancy

Aysha Aslam  1 , Karen Joanie Campoverde Reyes  1   2 , Vijayram Reddy Malladi  1 , Rizwan Ishtiaq  1 , Daryl T Y Lau  1
Affiliations
Review

Management of chronic hepatitis B during pregnancy

Aysha Aslam et al. Gastroenterol Rep (Oxf). 2018 Nov.

Abstract

Chronic hepatitis B is globally prevalent and is a major cause of cirrhosis and hepatocellular carcinoma. Despite immunoprophylaxis against hepatitis B in pregnancy, perinatal transmission still occurs in at least 10% of the children born to a mother with high level of viremia. Decisions regarding hepatitis B therapy during pregnancy must take into account the benefits and safety for both the mother and the unborn baby. In this review, we summarize the current treatment options for chronic hepatitis B with a focus on management during pregnancy and the evidence-based strategies to prevent vertical transmission of hepatitis B virus (HBV).

Keywords: Chronic hepatitis B; hepatitis B therapy; nucleoside analogue; pregnancy.

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Figures

Figure 1.
Figure 1.
Timeline based on FDA approval of drugs for hepatitis B management.
Figure 2.
Figure 2.
Management of pregnant women not on antiviral therapy prior to pregnancy.
Figure 3.
Figure 3.
Management of pregnant women on antiviral therapy prior to pregnancy.
See this image and copyright information in PMC

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