Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Nov;6(4):257-262.
doi: 10.1093/gastro/goy025. Epub 2018 Jul 24.

Management of chronic hepatitis B during pregnancy

Aysha Aslam  1 , Karen Joanie Campoverde Reyes  1   2 , Vijayram Reddy Malladi  1 , Rizwan Ishtiaq  1 , Daryl T Y Lau  1
Affiliations
Review

Management of chronic hepatitis B during pregnancy

Aysha Aslam et al. Gastroenterol Rep (Oxf). 2018 Nov.

Abstract

Chronic hepatitis B is globally prevalent and is a major cause of cirrhosis and hepatocellular carcinoma. Despite immunoprophylaxis against hepatitis B in pregnancy, perinatal transmission still occurs in at least 10% of the children born to a mother with high level of viremia. Decisions regarding hepatitis B therapy during pregnancy must take into account the benefits and safety for both the mother and the unborn baby. In this review, we summarize the current treatment options for chronic hepatitis B with a focus on management during pregnancy and the evidence-based strategies to prevent vertical transmission of hepatitis B virus (HBV).

Keywords: Chronic hepatitis B; hepatitis B therapy; nucleoside analogue; pregnancy.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Timeline based on FDA approval of drugs for hepatitis B management.
Figure 2.
Figure 2.
Management of pregnant women not on antiviral therapy prior to pregnancy.
Figure 3.
Figure 3.
Management of pregnant women on antiviral therapy prior to pregnancy.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Liu M, Li L, Zheng SJ et al. . Prevalence of major depression and its associations with demographic and clinical characteristics and quality of life in chinese patients with HBV-related liver diseases. Arch Psychiatr Nurs 2017;31:287–90. - PubMed
    1. WHO. Global Hepatitis Report 2017. Geneva: World Health Organization; 2017. http://www.who.int/hepatitis/publications/global-hepatitis-report2017/en/ (March 2018, date last accessed).
    1. Welch S, Chiang B, Shadday P et al. . Estimated prevalence of chronic hepatitis B (CHB) in foreign-born (FB) persons living in the United States (US) by country/region of origin. Hepatology 2008;48(Suppl 1):687A–8A. - PubMed
    1. Lok AS, McMahon BJ. Chronic hepatitis B: update 2009. Hepatology 2009;50:661–2. - PubMed
    1. Shi G, Zhang SX. Meta-analysis on the positive rate of hepatitis B surface antigen among pregnant women in China. Chin Prev Med 2013;1:26–30.