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Case Reports
. 2019 Jun;47(3):489-492.
doi: 10.1007/s15010-018-1249-7. Epub 2018 Nov 14.

Vaccine strain Listeria monocytogenes bacteremia occurring 31 months after immunization

Elias Fares  1   2 , Cindy B McCloskey  3 , Andres Gutierrez  4 , Michael Princiotta  4 , Linda J Salinas  1 , Douglas A Drevets  5   6
Affiliations
Case Reports

Vaccine strain Listeria monocytogenes bacteremia occurring 31 months after immunization

Elias Fares et al. Infection. 2019 Jun.

Abstract

Background: Listeria monocytogenes is a food-borne, facultative intracellular bacterium that causes severe diseases such as sepsis and meningoencephalitis in immunocompromised hosts. Because it stimulates robust T-lymphocyte-mediated responses, attenuated L. monocytogenes are candidate vaccine vectors for tumor immunotherapy.

Case: We report a case of bacteremia caused by vaccine strain L. monocytogenes (Axalimogene filolisbac) occurring 31 months after immunization against human papilloma virus (HPV) associated cervical cancer.

Conclusion: Receipt of a L. monocytogenes-based vaccine is a novel risk factor for delayed L. monocytogenes bacteremia.

Keywords: Immunotherapy; Live vaccine; Recurrent listeriosis. Listeria vaccine.

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