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Review
. 2019 Jan;19(1):15-22.
doi: 10.3892/mmr.2018.9627. Epub 2018 Nov 5.

Osteocalcin‑GPRC6A: An update of its clinical and biological multi‑organic interactions (Review)

Martha Cristina Diaz-Franco  1 , Raul Franco-Diaz de Leon  1 , Jose Rafael Villafan-Bernal  1
Affiliations
Review

Osteocalcin‑GPRC6A: An update of its clinical and biological multi‑organic interactions (Review)

Martha Cristina Diaz-Franco et al. Mol Med Rep. 2019 Jan.

Abstract

Osteocalcin is no longer regarded as a molecule exclusive to bone remodeling and osteogenesis, but as a hormone with manifold functions. The discovery of the interaction of osteocalcin with the G protein‑coupled receptor family C group 6‑member A (GPRC6A) receptor has accompanied the characterization of several roles that this peptide serves in body regulation and homeostasis. These roles include the modulation of memory in the brain, fertility in the testis, fat accumulation in the liver, incretins release in the intestine and adaptation to exercise in muscle, in addition to the well‑known effects on β‑cell proliferation, insulin release and adiponectin secretion. The aim of the present review was to provide a practical update of the multi‑organ effects that osteocalcin exerts through its interaction with GPRC6A and the clinical implications of this.

Keywords: osteocalcin; GPRC6A; glycaemia; diabetes; brain; vascular; liver; muscle; testis; intestine.

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Figures

Figure 1.
Figure 1.
Signal transduction triggered by osteocalcin binding to GPRC6A and their final target genes and biological effects. GPRC6A, G protein-coupled receptor family C group 6-member A.
Figure 2.
Figure 2.
Target organs of OC action, and the effects of high and low serum or expression levels. OC, osteocalcin; GLP-1, glucagon-like peptide type 1.
See this image and copyright information in PMC

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