Cancer antigen-125 levels correlate with pleural effusions and COPD-related complications in people living at high altitude

Abstract

Chronic obstructive pulmonary disease (COPD) is the most frequently encountered progressive lung disease in clinical practice. This study sought to determine the predictive ability of the tumor biomarker cancer antigen-125 (CA-125) in the identification of COPD in a cohort of 284 patients with COPD living at high altitude (with an average elevation of over 2500 m).Patients were classified by pleural effusion volumes into 4 categories and serum CA-125 concentrations were measured in each category. The analyses revealed that CA-125 concentrations were positively and significantly correlated with pleural effusion volume. CA-125 concentrations were also positively correlated with pulmonary heart disease and acute exacerbations of COPD, and negatively correlated with pulmonary hypertension.The study evidence suggests that serum CA-125 concentrations are positively correlated with the risk of pleural effusions among patients with COPD living in high-altitude areas, and that CA-125 concentrations are also correlated with pulmonary heart disease, acute exacerbations, and pulmonary hypertension.

Figure 1

Correlation of serum cancer antigen-125 (CA-125) concentration with pleural effusion volume. Serum CA-125 levels in patients with chronic obstructive pulmonary disease pleural effusion in each group. (A) Overall population; (B) Zang ethnic population; (C) Han ethnic population; (D) Hui ethnic population; (E) other ethnic population.