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Meta-Analysis
. 2018 Nov;97(46):e13061.
doi: 10.1097/MD.0000000000013061.

The relation of passive smoking with cervical cancer: A systematic review and meta-analysis

Benyu Su  1 , Wen Qin  2 , Feng Xue  3 , Xiaomin Wei  4 , Qiangdong Guan  1 , Wenchong Jiang  1 , Shue Wang  1 , Mengmeng Xu  1 , Sufang Yu  1
Affiliations
Meta-Analysis

The relation of passive smoking with cervical cancer: A systematic review and meta-analysis

Benyu Su et al. Medicine (Baltimore). 2018 Nov.

Abstract

Background: Published studies about passive smoking and cervical cancer have found inconsistent results. Hence, the present meta-analysis was performed to assess this association.

Methods: A systematical search was performed to identify eligible cohort and case-control studies in PubMed, Scopus, Elsevier ScienceDirect, and Web of Science databases (up to March, 2018). The quality of included studies was assessed by the Newcastle-Ottawa quality scale (NOS). The random effects model (REM) was used to calculate the pooled odds ratio (ORs). Subgroup and sensitivity analyses were performed. Publication bias was assessed by funnel plot, using Begg's test and Egger's test.

Results: Around 14 eligible studies were included for analysis, which included a total of 384,995 participants. The pooled ORs of passive smoking with cervical cancer risk was 1.70 (95% CI: 1.40-2.07, I = 64.3%). Subgroups stratified by continent, study design, quality score, and cervical cancer types/phases suggested that the result was robust. For instance, the pooled ORs for the cohort and case-control studies was 1.37 (95% CI: 1.16-1.62, I = 0%) and 2.09 (95% CI: 1.52-2.89, I = 76.6%), respectively. The pooled ORs ranged from 1.61 (95%CI: 1.34-1.92) to 1.77 (95%CI: 1.44-2.16) after one study was removed each time in the sensitivity analyses, indicating that the result was stable. Publication bias was detected by funnel plot and Egger's tests. The recalculated ORs were 1.33 (95% CI: 1.21-1.47).

Conclusions: This meta-analysis provides evidence that passive smoking is associated with an increased risk of cervical cancer.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
The flowchart of searching and selecting literatures.
Figure 2
Figure 2
Forest graph on the association of passive smoking with cervical cancer risk. The risk estimates and 95% CI from each study are shown by a square and segments, respectively. The overall summary relative risk is represented by a rhombus.
Figure 3
Figure 3
The result of sensitivity analysis.
Figure 4
Figure 4
Funnel plots on the association of passive smoking with cervical cancer risk.
See this image and copyright information in PMC

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