Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Jun;8(6):2651-4.
doi: 10.1128/mcb.8.6.2651-2654.1988.

B-raf, a new member of the raf family, is activated by DNA rearrangement

S Ikawa  1 , M Fukui, Y Ueyama, N Tamaoki, T Yamamoto, K Toyoshima
Affiliations

B-raf, a new member of the raf family, is activated by DNA rearrangement

S Ikawa et al. Mol Cell Biol. 1988 Jun.

Abstract

Complementary DNA clones of a putative transforming gene were isolated from NIH 3T3 cells transformed with human Ewing sarcoma DNA. The gene was termed B-raf because it is related to but distinct from c-raf and A-raf. It appears that substitution in the amino-terminal portion of the normal B-raf protein confers transforming activity to the gene.

PubMed Disclaimer

References

    1. Nucleic Acids Res. 1976 Sep;3(9):2303-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1972 Jun;69(6):1408-12 - PubMed
    1. Cell. 1978 Oct;15(2):687-701 - PubMed
    1. Biochemistry. 1979 Nov 27;18(24):5294-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1980 Mar;77(3):1398-402 - PubMed

Publication types

Associated data