MDVs: Spare the SOD and Spoil the Bug
- PMID: 30439336
- DOI: 10.1016/j.chom.2018.10.013
MDVs: Spare the SOD and Spoil the Bug
Abstract
Mitochondrial reactive oxygen species are important anti-microbial weapons utilized by phagocytes of the innate immune system. In this issue of Cell Host and Microbe, Abuaita et al. (2018) show that in macrophages, mitochondrial-derived vesicles deliver the superoxide dismutase Sod2 to bacteria-containing phagosomes to produce hydrogen peroxide and kill invading bacteria.
Copyright © 2018 Elsevier Inc. All rights reserved.
Comment on
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Mitochondria-Derived Vesicles Deliver Antimicrobial Reactive Oxygen Species to Control Phagosome-Localized Staphylococcus aureus.Cell Host Microbe. 2018 Nov 14;24(5):625-636.e5. doi: 10.1016/j.chom.2018.10.005. Epub 2018 Oct 25. Cell Host Microbe. 2018. PMID: 30449314 Free PMC article.
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