Review
[The so-called "contact" system of plasma: consequences of the activation of the Hageman factor]
[Article in
French]
Affiliations
- PMID: 3044204
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Review
[The so-called "contact" system of plasma: consequences of the activation of the Hageman factor]
[Article in
French]
Ann Biol Clin (Paris).
1988.
Abstract
The contact system of plasma includes 4 zymogens, Hageman factor, pre-kallikrein, factor XI and plasminogen, and a cofactor, the high molecular weight kininogen (HMWK). The activation of the contact system leads to the production of bradykinin, blood coagulation, fibrinolysis, complement activation and neutrophil stimulation. Consequently these phenomena generate a lot of pro-inflammatory factors which contribute to the local and systemic inflammatory processes.
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