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Review
. 1988;46(3):185-9.

[The so-called "contact" system of plasma: consequences of the activation of the Hageman factor]

[Article in French]
J Damas  1 , A Adam
Affiliations
  • PMID: 3044204
Review

[The so-called "contact" system of plasma: consequences of the activation of the Hageman factor]

[Article in French]
J Damas et al. Ann Biol Clin (Paris). 1988.

Abstract

The contact system of plasma includes 4 zymogens, Hageman factor, pre-kallikrein, factor XI and plasminogen, and a cofactor, the high molecular weight kininogen (HMWK). The activation of the contact system leads to the production of bradykinin, blood coagulation, fibrinolysis, complement activation and neutrophil stimulation. Consequently these phenomena generate a lot of pro-inflammatory factors which contribute to the local and systemic inflammatory processes.

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