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. 1988 Aug;15(8):2251-6.

[Comparison of methods for evaluating the nephrotoxicity of cisplatin]

[Article in Japanese]
K Suzumori  1 , Y Yasui, K Suzumori, Y Yagami, T Seki
Affiliations
  • PMID: 3044273

[Comparison of methods for evaluating the nephrotoxicity of cisplatin]

[Article in Japanese]
K Suzumori et al. Gan To Kagaku Ryoho. 1988 Aug.

Abstract

The BUN, serum creatinine, creatinine clearance and the urinary excretion of leucine aminopeptidase (LAP), alkaline phosphatase (ALP), beta 2-microglobulin (beta-m), and N-acetyl-beta-glucosaminidase (NAG), were measured in 21 gynecological cancer patients treated with CAPF (CPA + ADM + CDDP + 5-FU) to evaluate the sensitivity of these indices to renal tubular damage. After receiving CDDP almost all patients displayed an increase in excretion of beta-m but no urinary enzyme activities. However, NAG index (NAG activity/urinary creatinine) rose markedly in all patients. We concluded that NAG index is a valuable method in providing sensitive indices for detecting renal tubular damage caused by CDDP.

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