Correspondence: Osteonecrosis in childhood acute lymphoblastic leukemia: a retrospective cohort study of the Italian Association of Pediatric Haemato-Oncology (AIEOP)

Rosanna Parasole¹, Maria G Valsecchi², Daniela Silvestri^{2

3}, Franco Locatelli⁴, Elena Barisone⁵, Fara Petruzziello⁶, M Caterina Putti⁷, Concetta Micalizzi⁸, Antonella Colombini³, Rossella Mura⁹, Tommaso Mina¹⁰, Anna M Testi¹¹, Lucia D Notarangelo¹², Nicola Santoro¹³, Tommaso Casini¹⁴, Caterina Consarino¹⁵, Luca Lo Nigro¹⁶, Ottavio Ziino¹⁷, Giovanna Giagnuolo⁶, Carmelo Rizzari³, Valentino Conter³

Affiliations

¹ Department of Pediatric Hemato-Oncology, A.O.R.N. Santobono-Pausilipon, Naples, Italy. rparasol64@gmail.com.
² Center of Biostatistics for Clinical Epidemiology, Department of Health Science, University of Milano-Bicocca, Milan, Italy.
³ Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation/ASST Monza, Monza, Italy.
⁴ Department of Pediatric Hematology-Oncology, IRCCS "Bambino Gesù" Children's Hospital, Rome, and Department of Pediatrics, University of Pavia, Pavia, Italy.
⁵ Pediatric Onco-Hematology, Regina Margherita Children's Hospital, AOU Città della Salute e della Scienza, Turin, Italy.
⁶ Department of Pediatric Hemato-Oncology, A.O.R.N. Santobono-Pausilipon, Naples, Italy.
⁷ Department of Woman and Child Health, Laboratory of Haematology-Oncology, University of Padova, Padova, Italy.
⁸ Department of Pediatric Hematology-Oncology, IRCCS "Giannina Gaslini" Children's Hospital, Genoa, Italy.
⁹ Pediatric Hematology-Oncology, Ospedale Microcitemico, Cagliari, Italy.
¹⁰ Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
¹¹ Department of Cellular Biotechnologies and Hematogy, "Sapienza" University of Rome, Rome, Italy.
¹² Pediatric Hematology-Oncology, 'Spedali Civili', Brescia, Italy.
¹³ UOC di Pediatria ad indirizzo Oncoematologico Ospedaliera, Policlinico di Bari, Bari, Italy.
¹⁴ Pediatric Hematology-Oncology, IRCCS Meyer Children's Hospital, Florence, Italy.
¹⁵ Pediatric Hematology-Oncology, Azienda Ospedaliera Pugliese Ciaccio, Catanzaro, Italy.
¹⁶ Center of Pediatric Hemato-Oncology, Azienda Policlinico - OVE, Catania, Italy.
¹⁷ Department of Pediatric Haemato-Oncology, ARNAS Civico e Di Cristina, Palermo, Italy.

PMID: 30442887
PMCID: PMC6237817
DOI: 10.1038/s41408-018-0150-z

Correspondence: Osteonecrosis in childhood acute lymphoblastic leukemia: a retrospective cohort study of the Italian Association of Pediatric Haemato-Oncology (AIEOP)

Rosanna Parasole et al. Blood Cancer J. 2018.

. 2018 Nov 15;8(12):115.

doi: 10.1038/s41408-018-0150-z.

Authors

Affiliations

¹ Department of Pediatric Hemato-Oncology, A.O.R.N. Santobono-Pausilipon, Naples, Italy. rparasol64@gmail.com.
² Center of Biostatistics for Clinical Epidemiology, Department of Health Science, University of Milano-Bicocca, Milan, Italy.
³ Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, MBBM Foundation/ASST Monza, Monza, Italy.
⁴ Department of Pediatric Hematology-Oncology, IRCCS "Bambino Gesù" Children's Hospital, Rome, and Department of Pediatrics, University of Pavia, Pavia, Italy.
⁵ Pediatric Onco-Hematology, Regina Margherita Children's Hospital, AOU Città della Salute e della Scienza, Turin, Italy.
⁶ Department of Pediatric Hemato-Oncology, A.O.R.N. Santobono-Pausilipon, Naples, Italy.
⁷ Department of Woman and Child Health, Laboratory of Haematology-Oncology, University of Padova, Padova, Italy.
⁸ Department of Pediatric Hematology-Oncology, IRCCS "Giannina Gaslini" Children's Hospital, Genoa, Italy.
⁹ Pediatric Hematology-Oncology, Ospedale Microcitemico, Cagliari, Italy.
¹⁰ Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
¹¹ Department of Cellular Biotechnologies and Hematogy, "Sapienza" University of Rome, Rome, Italy.
¹² Pediatric Hematology-Oncology, 'Spedali Civili', Brescia, Italy.
¹³ UOC di Pediatria ad indirizzo Oncoematologico Ospedaliera, Policlinico di Bari, Bari, Italy.
¹⁴ Pediatric Hematology-Oncology, IRCCS Meyer Children's Hospital, Florence, Italy.
¹⁵ Pediatric Hematology-Oncology, Azienda Ospedaliera Pugliese Ciaccio, Catanzaro, Italy.
¹⁶ Center of Pediatric Hemato-Oncology, Azienda Policlinico - OVE, Catania, Italy.
¹⁷ Department of Pediatric Haemato-Oncology, ARNAS Civico e Di Cristina, Palermo, Italy.

PMID: 30442887
PMCID: PMC6237817
DOI: 10.1038/s41408-018-0150-z

No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

**Fig. 1**
a Five-year cumulative incidence of ON according to patient's age at ALL diagnosis. b–f Five-year cumulative incidence of osteonecrosis in ALL patients aged 10–17 years, according to different characteristics at diagnosis

See this image and copyright information in PMC

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References

1. te Winkel ML, Pieters R, Wind EJ, Bessems JH, van den Heuvel-Eibrink MM. Management and treatment of osteonecrosis in children and adolescent with acute lymphoblastic leukemia. Haematologica. 2014;99:430–436. doi: 10.3324/haematol.2013.095562. - DOI - PMC - PubMed
1. Girald P, et al. Symptomatic osteonecrosis in childhood leukemia survivors: prevalence, risk factors and impact on quality of life in adulthood. Haematologica. 2013;98:1089–1097. doi: 10.3324/haematol.2012.081265. - DOI - PMC - PubMed
1. Kunstreich M, Kummer S, Laws HJ, Borkhardt A, Kunlen M. Osteonecrosis in children with acute lymphoblastic leukemia. Haematologica. 2016;101:1295–1305. doi: 10.3324/haematol.2016.147595. - DOI - PMC - PubMed
1. Mattano LA, Jr, Sather HN, Trigg ME, Nachman JB. Osteonecrosis as a complication of treating acute lymphoblastic leukemia in children: a report from the Children’s Cancer Group. J. Clin. Oncol. 2000;18:3262–3272. doi: 10.1200/JCO.2000.18.18.3262. - DOI - PubMed
1. Burger B, et al. Osteonecrosis: a treatment related toxicity in children with acute lymphoblastic leukemia (ALL)-experiences from trials ALL-BFM 95. Pediatr. Blood. Cancer. 2005;44:220–225. doi: 10.1002/pbc.20244. - DOI - PubMed

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Correspondence: Osteonecrosis in childhood acute lymphoblastic leukemia: a retrospective cohort study of the Italian Association of Pediatric Haemato-Oncology (AIEOP)

Affiliations

Correspondence: Osteonecrosis in childhood acute lymphoblastic leukemia: a retrospective cohort study of the Italian Association of Pediatric Haemato-Oncology (AIEOP)

Authors

Affiliations

Conflict of interest statement

Figures

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