[Patho- and morphogenesis of diabetes mellitus and early diabetic nephropathy]

Abstract

Heterogeneity of diabetes mellitus, as the specialists see it nowadays, is determined by the presence of histocompatibility antigens and the onset of immune autoaggression against beta-cells of islet of Langerhans which leads to formation of circulating immune complexes and complexes in situ. This may give rise to diabetic nephropathy. In florid diabetes mellitus there also appeared disturbances induced by metabolic derangement, relevant antigens being then exogenic insulin and low-molecular lipoproteins entailing drastic changes of the basal membrane of glomerular capillaries, plasma saturation of the vascular walls and eventual hyalinosis and capillary obliteration.