Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Nov 13;2018(11):rjy300.
doi: 10.1093/jscr/rjy300. eCollection 2018 Nov.

Objective demonstration of improvement of neurogenic bowel dysfunction in a case of spinal cord injury following stem cell therapy

H Guadalajara Labajo  1 , M León Arellano  1 , J Vaquero Crespo  2 , I Valverde Núñez  3 , D García-Olmo  1
Affiliations
Case Reports

Objective demonstration of improvement of neurogenic bowel dysfunction in a case of spinal cord injury following stem cell therapy

H Guadalajara Labajo et al. J Surg Case Rep. .

Abstract

Constipation in spinal cord injury patients is a frequent complication that leads to a reduction of quality of life, extensive psychological and economic strain on patients and healthcare systems. We report a 58-year-old man with an incomplete SCI secondary to L1 vertebral fracture, presented gait disorder with neurogenic bowel and bladder dysfunction. He received 300 million autologous mesenchymal stromal cells (MSC) in the subarachnoid space by lumbar puncture. After the third administration of MSC the patient had an important improvement in almost every functional scale of spinal cord injury, especially in the Krogh's Neurogenic Bowel Dysfunction scale. Our present observation supports recent clinical findings about the benefit of autologous stem cell therapy for the improvement of bowel dysfunction in patients suffering spinal cord injury.

PubMed Disclaimer

Figures

Figure 1:
Figure 1:
MRI: spinal cord injury secondary to L1 vertebral fracture.
Figure 2:
Figure 2:
Dynamic MRI: incomplete contrast evacuation.
Figure 3:
Figure 3:
Dynamic MRI: complete contrast evacuation.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Lynch AC, Anthony A, Dobbs BR, Frizelle FA. Anorectal physiology following spinal cord injury. Spinal Cord 2000;38:573–80. October 01. - PubMed
    1. Rasmussen MM, Rawashdeh YF, Clemmensen D, Tankisi H, Fuglsang-Frederiksen A, Krogh K, et al. . The artificial somato-autonomic reflex arch does not improve lower urinary tract function in patients with spinal cord lesions. J Urol 2015;193:598–604. - PubMed
    1. Badner A, Siddiqui AM, Fehlings MG. Spinal cord injuries: how could cell therapy help? Expert Opin Biol Ther 2017;17:529–41. May. - PubMed
    1. Garcia-Arranz M, Herreros MD, Gonzalez-Gomez C, de la Quintana P, Guadalajara H, Georgiev-Hristov T, et al. . Treatment of Crohn’s-related rectovaginal fistula with allogeneic expanded-adipose derived stem cells: a phase I-IIa clinical trial. Stem Cells Transl Med 2016;5:1441–6. November 01. - PMC - PubMed
    1. Vaquero J, Zurita M, Rico MA, Bonilla C, Aguayo C, Montilla J, et al. . An approach to personalized cell therapy in chronic complete paraplegia: the puerta de hierro phase I/II clinical trial. Cytotherapy 2016;18:1025–36. August 01. - PubMed

Publication types