Gut microbes modulate host response to immune checkpoint inhibitor cancer immunotherapy

Kebin Liu^{1

2}, Chunwan Lu^{1

2}

Affiliations

¹ Department of Biochemistry and Molecular Biology, Georgia Cancer Center, Medical College of Georgia, Augusta, GA 30912, USA.
² Cancer Immunology, Inflammation and Tolerance Program, Georgia Cancer Center, Medical College of Georgia, Augusta, GA 30912, USA.

Comment

Kebin Liu et al. Transl Cancer Res. 2018 Jun.

. 2018 Jun;7(Suppl 5):S608-S610.

doi: 10.21037/tcr.2018.05.37.

Kebin Liu^{1

2}, Chunwan Lu^{1

2}

¹ Department of Biochemistry and Molecular Biology, Georgia Cancer Center, Medical College of Georgia, Augusta, GA 30912, USA.
² Cancer Immunology, Inflammation and Tolerance Program, Georgia Cancer Center, Medical College of Georgia, Augusta, GA 30912, USA.

No abstract available

Conflict of interest statement

Footnote Conflicts of Interest: The authors have no conflicts of interest to declare.

Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.
Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillère R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, Fidelle M, Flament C, Poirier-Colame V, Opolon P, Klein C, Iribarren K, Mondragón L, Jacquelot N, Qu B, Ferrere G, Clémenson C, Mezquita L, Masip JR, Naltet C, Brosseau S, Kaderbhai C, Richard C, Rizvi H, Levenez F, Galleron N, Quinquis B, Pons N, Ryffel B, Minard-Colin V, Gonin P, Soria JC, Deutsch E, Loriot Y, Ghiringhelli F, Zalcman G, Goldwasser F, Escudier B, Hellmann MD, Eggermont A, Raoult D, Albiges L, Kroemer G, Zitvogel L. Routy B, et al. Science. 2018 Jan 5;359(6371):91-97. doi: 10.1126/science.aan3706. Epub 2017 Nov 2. Science. 2018. PMID: 29097494

1. Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 2012;486:207–14. - PMC - PubMed
1. Human Microbiome Project Consortium. A framework for human microbiome research. Nature 2012;486:215–21. - PMC - PubMed
1. Routy B, Le Chatelier E, Derosa L, et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science 2018;359:91–7. - PubMed
1. Zou W, Wolchok JD, Chen L. PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations. Sci Transl Med 2016;8:328rv4. - PMC - PubMed
1. Boussiotis VA. Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway. N Engl J Med 2016;375:1767–78. - PMC - PubMed