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. 2018 Oct 14:11:2516865718803641.
doi: 10.1177/2516865718803641. eCollection 2018.

Histone Modifications: Epigenetic Mediators of Environmental Exposure Memory

Jessica Camacho  1 , Patrick Allard  1   2
Affiliations

Histone Modifications: Epigenetic Mediators of Environmental Exposure Memory

Jessica Camacho et al. Epigenet Insights. .

Abstract

How organisms retain a memory of ancestral environmental exposure is a phenomenon that is still poorly understood. Recently published work by our group and others, regarding environmentally induced transgenerational effects, have identified an array of mechanisms, with a particular focus on histone modifications, that shed some light on the underlying epigenetic processes driving long-term generational effects.

Keywords: Bisphenol A; C. elegans; histone demethylase; reproductive function; transgenerational inheritance.

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Conflict of interest statement

Declaration of conflicting interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
BPA exposures in C. elegans reduces the levels of the repressive histone marks H3K9me3 and H3K27me3, regulated by the demethylases jmjd-2 and jmjd-3/utx-1, respectively. This disruption causes a de-silencing effect and reproductive dysfunction observed from the P0 generation until the F4. The F3 generation represents the first generation where there was no direct contact with the environmental toxicant (BPA).
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